Shiga toxin-induced Haemolytic Uraemic Syndrome and the role of antibiotics

Antibiotic administration in Shiga toxin producing E. coli (STEC) infections is a topic of great controversy. As the role of shiga toxin (Stx) is central to the development of hemolytic uremic syndrome (HUS), it's not surprising that an increase in its production or release would be expected to have catastrophic consequences. The two toxins produced by STEC, Stx1 and Stx2, appear to differ significantly in their potency to induce protein synthesis inhibition and cytotoxicity, with some subtypes of Stx2 being more potent than Stx1, while other subtypes have similar potency.
Source: Journal of Infection - Category: Infectious Diseases Authors: Tags: Review Source Type: research