Inhibitory effect of recombinant human CXCL8(3-72)K11R/G31P on atherosclerotic plaques in a mouse model of atherosclerosis.

Conclusions: These findings indicate the potential therapeutic effects of G31P in suppressing the development of atherosclerosis by antagonizing the IL-8 receptor. G31P inhibits the proliferation and migration of VSMCs through regulating the Rho-kinase, ERK, and calcium-dependent pathways. PMID: 31124391 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31124391?dopt=Abstract

Source: Immunopharmacology and Immunotoxicology - May 29, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research