Classifying Mood Symptom Trajectories in Adolescents with Bipolar Disorder

The Course and Outcome of Bipolar Youth study (Birmaher and colleagues) found that children and adolescents with bipolar spectrum disorders followed one of four distinct mood trajectories over 8 years of follow-up, with as many as 25% showing a predominantly euthymic course. We evaluated whether similar patterns of illness course are observed in adolescents with bipolar I and II disorder who participated in a 2-year clinical trial.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: New Research Source Type: research

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In conclusion, the Prevotella 2 and Ruminococcaceae UCG-002 genera were identified as potential candidates for distinguishing bipolar disorder and major depressive disorder. Further studies with larger sample sizes, longitudinal designs, and control for other various confounders are warranted.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Publication date: Available online 21 January 2020Source: Journal of Electroanalytical ChemistryAuthor(s): Jinghan Chen, Jie Zhang, Jingtang Qiao, Meisheng WuAbstractResistance is of great importance for controlling the current flow through bipolar electrodes (BPEs) and the electrochemiluminescence (ECL) signal at the BPE anode. In this work, we firstly studied the effect of the iR drop between the BPE cathode and anode on the electrochemical performance of a closed BPE device. Due to the significant iR loss between the two poles of the BPE, an increased external voltage, applied on the driving electrodes, was required to ...
Source: Journal of Electroanalytical Chemistry - Category: Chemistry Source Type: research
IntroductionDepressive and manic episodes of bipolar disorder can interact with sleep complaints, followed by a worsened psychiatric condition. The aim of this study was to examine the interaction of sleep disorders with bipolar disorder in youths during depressive and manic episodes.MethodsThe target population was children and adolescents drawn from the Children and Adolescents Affective Disorder Program. Clinical assessment for current psychiatric diagnosis was done by direct clinical interview, Diagnostic Interview for Children and Adolescents (DSM-IV), and best-estimated clinical consensus. We applied sleep questionna...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Mental health issues affect billions of people across every corner of the globe, touching every community and every family, and mounting evidence shows the issue is worsening. To combat the issue, we need to urgently grow our investment in programs that expand access to care, mental health advocates said at a TIME lunch on Wednesday in Davos, Switzerland. “Invest in the system, invest in our rights,” said Elisha London, founder and CEO of United for Global Mental Health. She called for $1 billion in spending on mental health programs worldwide: “It has to happen now.” The event, held during the annu...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized DavosMentalHealth mental health Source Type: news
Condition:   Bipolar Depression Interventions:   Drug: Mydayis Extended-Release Capsule;   Drug: Placebo Sponsors:   Mayo Clinic;   Lindner Center of HOPE Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Publication date: 21 January 2020Source: Cell Reports, Volume 30, Issue 3Author(s): Haruka Yamamoto, Tetsuo Kon, Yoshihiro Omori, Takahisa FurukawaSummaryOtx family homeoproteins Otx2 and Crx are expressed in photoreceptor precursor cells and bind to the common DNA-binding consensus sequence, but these two proteins have distinct functions in retinal development. To examine the functional substitutability of Otx2 and Crx, we generate knockin mouse lines in which Crx is replaced by Otx2 and vice versa. We find that Otx2 and Crx cannot be substituted in photoreceptor development. Subsequently, we investigate the function of O...
Source: Cell Reports - Category: Cytology Source Type: research
CONCLUSIONS: This study demonstrates the potential of the Mood Outcomes Program to create a nationwide "learning health system" for mood disorders. This goal will be further realized as the program expands in reach and scope across additional NNDC sites. PMID: 31960777 [PubMed - as supplied by publisher]
Source: Psychiatric Services - Category: Psychiatry Tags: Psychiatr Serv Source Type: research
Comorbidity is the presence of one or more additional conditions co-occurring with a primary condition. In this episode, host schizophrenic Rachel Star Withers with her cohost Gabe Howard will be discussing comorbidity with schizophrenia. Comorbidity is associated with worse health outcomes, more complex clinical management and increased health care costs. Occupational therapist and host of the podcast Occupied, Brock Cook, will be joining us to discuss ways that he works with people with schizophrenia to manage multiple health issues.  Highlights from “Comorbidity with Schizophrenia” Episode [01:28] What ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Antipsychotic Inside Schizophrenia Mental Health and Wellness Psychiatry Psychology Psychotherapy Bipolar disorder and schizophrenia comorbid comorbid psychiatric conditions Comorbidities Comorbidity Diagnosis Of Schizophrenia Livi Source Type: blogs
Authors: Ali Z, Tegin C, El-Mallakh RS Abstract Introduction: Lurasidone has been approved in the United States as a monotherapy and adjunct for acute bipolar I depression, as well as an antipsychotic for patients with schizophrenia.Areas covered: Herein, the authors review the pharmacodynamics and pharmacokinetics of lurasidone as well and the major randomized clinical trials. The authors also provide their expert opinion.Expert opinion: Lurasidone has not been studied in patients with mania or bipolar psychosis. It has been studied, both as a monotherapy and adjunctive treatment to lithium or valproate, in acute ...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Publication date: Available online 21 January 2020Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Ari B. Cuperfain, James L. Kennedy, Vanessa F. GoncalvesAbstractCognitive impairment is highly prevalent in the progression of both diabetes mellitus and bipolar disorder. The relationship between insulin resistance in diabetes and the risk of developing major neurocognitive disorders such as Alzheimer’s disease has been well described. Insulin resistance and the associated metabolic deficiencies lead to biochemical alteration which hasten neurodegeneration and subsequent cognitive impairment. For bipolar disor...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
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