Interim report: segregation in mental health wards for children and young people and in wards for people with a learning disability or autism.

This interim report from the CQC review of restraint, prolonged seclusion and segregation for people with a mental health problem, a learning disability and or autism presents initial findings on the use of long-term segregation on mental health wards for children and young people and wards for people with a learning disability and/or autism. The final report will be published in Spring 2020. In the meantime, the CQC has made a number of recommendations for immediate action.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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AbstractBecause early intervention often leads to the best outcomes in children with autism spectrum disorder (ASD), it is important that these children are identified as early as possible. Therefore, exploration of tools that could be used to identify at-risk children at an early age is needed. Such a tool could assist health professionals and their decision about whether to refer an individual for a full diagnostic assessment for ASD. Several studies have demonstrated and supported the use of screening algorithms created from measures of developmental functioning. The purpose of the current study was to explore the relat...
Source: Journal of Developmental and Physical Disabilities - Category: Disability Source Type: research
In this study, whole-exome sequencing was performed to detect potential pathogenic de novo mutations, and finally we identified a novel damaging de novo mutation in SEMA5A and a compound heterozygous mutation in CLTCL1 in three sporadic trios with IS. The expression profiling of SEMA5A in human brain showed that it was mainly highly expressed in the cerebral cortex during early brain development stage (8-9 post-conception weeks and 0-5 month after birth). In addition, we identified a close protein-protein interaction network between SEMA5A and candidate genes associated with epilepsy, autism spectrum disorder (ASD) or inte...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Abstract This randomized controlled study evaluated a computer-based intervention on emotion understanding in 32 children with autism spectrum conditions with and without intellectual disability (ID) aged 7-15 years. The intervention group (n = 16) used the program for 12 h while the control group (n = 16) was not included in any intervention or training beside the usual educational curriculum. After controlling for pre-intervention scores and symptom severity, strong positive effects were observed in emotion recognition from real face photographs and pictograms, as well as in...
Source: Journal of Autism and Developmental Disorders - Category: Psychiatry Authors: Tags: J Autism Dev Disord Source Type: research
ConclusionThe presented patient is the second with a pathogenicMBD5 mutation in whom the course of disease is suggestive of early onset dementia starting in her fifth decade. These findings stress the importance of exome sequencing, also in elderly intellectually disabled patients, particularly in those with autism.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusions: Our findings highlight that disclosing a condition of autism in the workplace and requesting accommodations is complex. More research is needed to explore processes of disclosing and accommodation and how these processes vary by autism sub-type, gender, and industry type. Implications for rehabilitation Clinicians and vocational Counselors should support people with autism to advocate for their needs in the workplace, including the potential benefits of disclosing their conditions so they can access accommodations that allow them to keep healthy and productive in workplace. Clinicians should recognize that peo...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
In this study, 80 Jordanian children under the age of 12 with diagnosed autism were selected. For comparison, 51 unaffected siblings and 86 unrelated healthy controls were also recruited. Venous blood was collected and interleukin levels in all three groups were investigated. Results: Interleukin-6 was found to be significantly higher in the plasma of both autistic children and their siblings compared with the unrelated healthy control group (P
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
If you’re one of the many homeowners considering using this summer to repaint your house or apartment, you might have been concerned to hear that, according to a just-published study in the journal Occupational &Environmental Medicine, women exposed to common paint chemicals at work are more likely to have a child with autism spectrum disorder. Further, the greater the exposure, the greater the autism risk, the study found. These risks remained even after the researchers adjusted their data to account for other potential autism factors, such as a woman’s smoking history, alcohol habits, and age at the time ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Source Type: news
This study examined sex differences in externalizing and internalizing symptoms of children with ASD without intellectual disability (ID). The sample (n = 80) included 40 girls and 40 boys, ages 6-12 years, with ASD (without ID) matched on age and IQ. Externalizing and internalizing symptoms were significantly elevated for this sample (girls and boys) relative to normative estimates for all the scales (hyperactivity, aggression, anxiety, and depression) except conduct problems. No significant differences were found between girls and boys for either externalizing symptoms or internalizing symptoms (based ...
Source: Journal of Autism and Developmental Disorders - Category: Psychiatry Authors: Tags: J Autism Dev Disord Source Type: research
Discussion The negative effect of poverty and toxic stress on children born preterm, as depicted by the eco-bio-developmental model, is supported by this analysis. Healthcare providers are encouraged to address the tripartite vulnerability resulting from prematurity, poverty, and toxic stress.
Source: Nursing Research - Category: Nursing Tags: FEATURE ARTICLES Source Type: research
AbstractActivity-dependent neuroprotective protein (ADNP) is essential for embryonic development withADNP mutations leading to syndromic autism, coupled with intellectual disabilities and motor developmental delays. Here, mining human muscle gene-expression databases, we have investigated the association ofADNP transcripts with muscle aging. We discovered increasedADNP and its paralogueADNP2 expression in the vastus lateralis muscle of aged compared to young subjects, as well as altered expression of theADNP and theADNP2 genes in bicep brachii muscle of elderly people, in a sex-dependent manner. Prolonged exercise resulted...
Source: AGE - Category: Geriatrics Source Type: research
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