Role of Apolipoprotein E, Cathepsin D, and Brain-Derived Neurotrophic Factor in Parkinson ’s Disease: A Study from Eastern India

This study suggests thatAPOE andBDNF may serve as modifier loci among eastern Indian PD patients.
Source: NeuroMolecular Medicine - Category: Neurology Source Type: research

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The ability to perceive differences in environmental contrast is critical for navigating complex environments safely. People with Parkinson's disease (PD) report a multitude of visual and cognitive deficits which may impede safe obstacle negotiation and in...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Publication date: 12 June 2020Source: Journal of Ethnopharmacology, Volume 255Author(s): Albert Katchborian-Neto, Wanderleya T. Santos, Karen J. Nicácio, José O.A. Corrêa, Michael Murgu, Thaís M.M. Martins, Dawidson A. Gomes, Alfredo M. Goes, Marisi G. Soares, Danielle F. Dias, Daniela A. Chagas-Paula, Ana C.C. Paula
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: Khosravi S, Harner ME Abstract Mitochondria perform a plethora of functions in various cells of different tissues. Their architecture differs remarkably, for instance in neurons versus steroidogenic cells. Furthermore, aberrant mitochondrial architecture results in mitochondrial dysfunction. This indicates strongly that mitochondrial architecture and function are intimately linked. Therefore, a deep knowledge about the determinants of mitochondrial architecture and their function on a molecular level is of utmost importance. In the past decades, various proteins and protein complexes essential for formatio...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
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Source: Neurology Today - Category: Neurology Tags: In the Pipeline Source Type: research
No abstract available
Source: Neurology Today - Category: Neurology Tags: Disease Mechanisms Source Type: research
Molecules, Vol. 25, Pages 1633: PET Imaging of the Adenosine A2A Receptor in the Rotenone-Based Mouse Model of Parkinson’s Disease with [18F]FESCH Synthesized by a Simplified Two-Step One-Pot Radiolabeling Strategy Molecules doi: 10.3390/molecules25071633 Authors: Susann Schröder Thu Hang Lai Magali Toussaint Mathias Kranz Alexandra Chovsepian Qi Shang Sladjana Dukić-Stefanović Winnie Deuther-Conrad Rodrigo Teodoro Barbara Wenzel Rareş-Petru Moldovan Francisco Pan-Montojo Peter Brust The adenosine A2A receptor (A2AR) is regarded as a particularly appropriate target for non-dopa...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
The evidence demonstrating the benefits of exercise is indisputable for healthy subjects, and more recently, it is growing for Parkinson's disease (PD) patients. Due to its easy access, low cost, social facilitation and, above all, the symptomatic effect, clinical exercise may have a profound impact on PD management. Especially considering that in recent decades there have been no major advances from the pharmacological point of view. Despite this, clinical exercise use it stills limited by the existent flaws in the available evidence supporting its use and guiding its prescription as a PD therapeutic intervention. We beli...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
ConclusionsAll of the above findings suggested that pSS is an independent risk factor for the development of PD.Key Points•The patients with pSS had 1.23 times risk of Parkinson disease than the non-pSS group.•The female patients with pSS and patients aged between 61 and 70 years were associated with a higher PD risk (aHR 1.28 and aHR 1.30, respectively).•The pSS patients with comorbidity had highest risk of PD (aHR: 3.814).
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
In conclusion, the different severities of glaucoma do not alter the incidence of subsequent dementia.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
WEDNESDAY, April 1, 2020 -- Telephone-based cognitive behavioral therapy (T-CBT) seems to be an effective intervention for depression in Parkinson disease (PD), outperforming treatment-as-usual (TAU) on all depression, anxiety, and quality-of-life...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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