Hepatocellular Carcinoma of Fibrolamellar Type in an Adolescent: Case Report and Literature Review

We present a female patient, 13 years old, with diagnosis of hepatocellular carcinoma of fibrolamellar type, which was rapidly evolving. The fibrolamellar hepatocellular carcinoma invaded more than 80% of the hepatic parenchyma without surgical possibility or liver transplantation. Measures applied corresponded to chemotherapy of 1 cycle of cisplatin 40 mg/s/5 days + vincristine 1.5 mg/m2/day, 5-fluorouracil, doxorubicin, and dexrazoxane. The case presented aggressive evolution of hepatocellular carcinoma, which led to acute liver failure, with hyperammonemia, sepsis, pulmonary focus plus septic shock, grade III-IV encephalopathy, portal hypertension, and ascites with intra-abdominal hypertension. Death occurred due to multiple organ failure, which involved respiratory failure type KDIGO 1 and 2, acute liver failure, severe pneumonia, pericardial effusion, AKIN 2 acute kidney injury, carcinoma, and pulmonary metastasis. This type of ailment is infrequent in children and adolescents, and the first symptoms are crucial to achieve treatment possibilities.Gastrointest Tumors
Source: Gastrointestinal Tumors - Category: Gastroenterology Source Type: research

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ConclusionIt is feasible to use CNN based algorithm to accurately distinguish cancerous regions in OCT images. This fully automated method can overcome limitations of manual interpretation including interobserver variability and speed of interpretation and may enable real-time intraoperative margin assessment.
Source: Academic Radiology - Category: Radiology Source Type: research
Publication date: Available online 17 July 2019Source: Academic RadiologyAuthor(s): Mandi Wang, Jose A.U. Perucho, Queenie Chan, Jianqing Sun, Philip Ip, Ka Yu Tse, Elaine Y.P. LeeRationale and ObjectivesTo evaluate the additional value of diffusion kurtosis imaging (DKI) in the characterization of cervical carcinoma.Materials and MethodsSeventy-five patients (56.9 ± 13.4 years) with histologic-confirmed cervical carcinoma were included. Diffusion-weighted imaging (DWI) was acquired on a 3T MRI with five b values (0, 500, 800, 1000, and 1500 s/mm2). Data were analyzed based on DKI model (5 b values) and conventional...
Source: Academic Radiology - Category: Radiology Source Type: research
LM Abstract Sepsis is a condition characterized by a severe stage of blood-infection often leading to tissue damage, organ failure and finally death. Fast diagnosis and identification of the sepsis stage (sepsis, severe sepsis or septic shock) is critical for the patient's evolution and could help in defining the most adequate treatment in order to reduce its mortality. The combined detection of several biomarkers in a timely, specific and simultaneous way could ensure a more accurate diagnosis. We have designed a new optical point-of-care (POC) device based on a phase-sensitive interferometric biosensor with a l...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
We report a case of retinoblastoma regression in the untreated eye following IAC to the contralateral eye.
Source: Saudi Journal of Ophthalmology - Category: Opthalmology Source Type: research
Stevie Wonder will receive a kidney transplant in the coming months. Kidney disease is surprisingly common, especially in minority populations. Kidney donation can be performed from a living donor, and can be scheduled as opposed to performed as an emergency surgery.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
Healthcare-associated infections (HAIs) continue to be an ongoing threat to patients. “Despite the best care, patients get infections,” Brian Gross, business lead, genomics for infectious disease at Philips, told MD+DI. Because they are “technically avoidable, there’s pressure on hospitals to drive their numbers down.” Healthcare system professionals have struggled with two main problems when trying to identify and act on infection risks, Gross explained. “The problem is two-fold. First, because of current tools, all...
Source: MDDI - Category: Medical Devices Authors: Tags: Software Source Type: news
HIGH blood pressure can lead to serious and even life-threatening health conditions if left untreated, so doing what you can to prevent a high reading is very important. Studies have shown the following three supplements to lower high blood pressure readings.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
ConclusionsDental brushing performed before surgery by a pediatric dentist was effective in reducing the incidence of postoperative pneumonia in pediatric patients.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
ConclusionsThis study brings out consequential information on factors linked with invaded or insufficient excision margins. Larger cohorts should evaluate the aesthetic outcomes in such a population.
Source: Journal of Cranio Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: Available online 16 July 2019Source: International Journal of PharmaceuticsAuthor(s): Zhonghui Xie, Zhenhai Zhang, Huixia LvAbstractRapamycin as a novel macrolide immunosuppressive agent has been commonly used in organ transplantation owing to its stronger immunosuppressive effect, non-nephrotoxicity and lower side effect. However its drawbacks of low bioavailability and big individual difference remain to be improved in clinical application. Here rapamycin loaded TPGS-Lecithins-Zein nanoparticles (RTLZ-NPs) with core-shell structure were prepared by the phase separation method. The RTLZ-NPs were approxim...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
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