RCT: Prevention of contrast-induced nephropathy with sodium-potassium citrate

Source: Eur Heart J Area: News Contrast-induced nephropathy (CIN) is a frequent complication of many radiological procedures involving the application of contrast media. A number of methods have been proposed for the prevention of CIN, including the alkalinisation of urine. Sodium-potassium (Na/K) citrate is a well-known agent for urine alkalinisation, and is mainly administered to patients with kidney stones. It has not been studied in the prevention of CIN.   Researchers tested the hypothesis that alkalinisation of urine, using Na/K citrate, reduces the frequency of contrast nephropathy in patients after coronary angiography. They conducted an RCT in 202 patients who were randomised to the Na/K citrate or to the control group.   Patients randomised to Na/K group received hexakalium-hexanatrium-trihydrogen-pentacitrat (5 g diluted in 200 mL of water). Urinary pH was measured immediately before coronary angiography, i.e. 1 hour after the administration of the medicine. Four hours after the ...
Source: NeLM - News - Category: Drugs & Pharmacology Source Type: news