Characterization of BRCA1 and BRCA2 genetic variants in a cohort of Bahraini breast cancer patients using next ‐generation sequencing

ConclusionOur data suggest thatBRCA1/2 variants may contribute to the pathogenesis of familial breast cancer in Bahrain. It also shows that NGS is useful tool for screeningBRCA1/2 genetic variants of probands and unaffected relatives.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research

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In conclusion, the addition of PPIs to the treatment regimen of breast cancer appears to be a promising strategy to potentiate the efficacy of chemotherapy and may suppress cancer metastasis. PMID: 31955147 [PubMed - in process]
Source: Acta Pharmaceutica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharm Source Type: research
Abstract A series of nine new 2,3-disubstituted 4(3H)-quinazolin-4-one derivatives was furnished starting from the 2-propyl-4(3H)-quinazo-line-4-one (2). The reinvestigation of the key starting quinazolinone 2 was performed under microwave irradiation (MW) and solvent-free conditions. Combination of MW and phase-transfer catalysis using tetrabutylammonium benzoate (TBAB) as a novel neutral ionic catalyst was used for carrying out N-alkylation and condensation reactions of compound 2 as a simple, efficient and eco-friendly technique. The structure of the synthesized compounds was elucidated using different spectral...
Source: Acta Pharmaceutica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharm Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Cancer Research UK scientists working in Cambridge made a vital energy-producing chemical magnetic and used MRI scans to watch how quickly breast cancer cells used it up.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
I am currently in my senior year of undergrad, and i honestly don't know what my chances of getting into a mid-tier medical school is since my scores are kinda low average. I personally feel i am a little different because im ADHD and Dyslexic and coupled with my experience as a whole. Currently, i have a 3.4 overall GPA scored a 505 on the MCAT The second author on Triple-negative Metaplastic Breast Cancer research paper. I work full time as a Regional Representative for a hemp company... WAMC since i am out the ordinary case
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Nontraditional Students Source Type: forums
Breast cancer progression can vary significantly between patients. Even within the same tumor, different areas may be composed of different types of cells and characterized by different tumor structures. This heterogeneity makes it challenging to ascertain the severity of a tumor and assess its molecular subtype, thereby affecting the precision of diagnosis and the choice of the most effective treatment approach.
Source: eHealth News EU - Category: Information Technology Tags: Featured Research Research and Development Source Type: news
(Cancer Research UK) A new type of scan that involves magnetizing molecules allows doctors to see in real-time which regions of a breast tumor are active, according to research funded by Cancer Research UK and published in Proceedings of the National Academy of Sciences today. This is the first time researchers have demonstrated that this scanning technique, called carbon-13 hyperpolarized imaging, can be used to monitor breast cancer.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
(University of Zurich) An imaging approach developed at UZH enables the study of breast cancer tissue in greater detail. It uses 35 biomarkers to identify the different cell types in breast tumors and its surrounding area compared to the current standard of testing single markers. This increases the precision of tumor analysis and classification - and improves personalized diagnostics for breast cancer patients.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
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