Population Pharmacokinetics of Alemtuzumab (Campath) in Pediatric Hematopoietic Cell Transplantation: Towards Individualized Dosing to Improve Outcome

ConclusionThe current practice with uniform milligram/kilogram doses leads to highly variable exposures in children due to the non-linear relationship between body weight and alemtuzumab PK. This model may be used for individualized dosing of alemtuzumab.

http://link.springer.com/10.1007/s40262-019-00782-0

Source: Clinical Pharmacokinetics - May 26, 2019 Category: Drugs & Pharmacology Source Type: research