Glycosidic compounds from Cassia obtusifolia seeds and their inhibitory effects on OATs, OCTs and OATPs

Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Shuangyan Wang, Keyu Feng, Lifeng Han, Xin Fang, Youcai Zhang, Heshui Yu, Xu PangAbstractPhytochemical work on water-soluble ingredients extracted from Cassia obtusifolia seeds led to the isolation of twelve glycosidic compounds including three chromone C-glycosides (1-3), two anthraquinone glycosides (4, 5), six naphthopyran glycosides (6-11), and one naphthalene glycoside (12). The structures of all compounds were identified mainly by spectroscopic data analysis; 1-3 were three new chromone C-glycosides, and 4 was a new anthraquinone glycoside. All isolates were evaluated for the inhibitory activities against human organic anion/cation transporters (OATs/OCTs) and organic anion transporting polypeptides (OATPs) The results demonstrated that compound 7 exhibited a moderate inhibitory effect on OAT3, while 5 showed a moderate effect on OCT1. Compounds 4, 6, 8 and 10 displayed a moderate inhibitory effect on OATP1B3, and 10 inhibits OATP2B1 significantly.Graphical abstractThree chromone C-glycosides and one new anthraquinone glycoside were obtained from Cassia obtusifolia seeds.
Source: Phytochemistry Letters - Category: Chemistry Source Type: research

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Publication date: Available online 17 July 2019Source: Journal of Integrative MedicineAuthor(s): Pierre Watcho, Ismaelle Rosine Mpeck, Patrick Brice Defo Deeh, Modeste W.eu-Nya, Esther Ngadjui, Georges Romeo Fozin Bonsou, Pierre Kamtchouing, Albert KamanyiAbstractObjectiveCyclophosphamide (CP) is commonly used to treat some cancers, but its clinical efficacy is also linked with testicular toxicity. We investigated the effects of aqueous extract (AE) and methanolic extract (ME) of Helichrysum odoratissimum for reducing CP-induced reproductive toxicity in male rats.MethodsIn addition to a normal control (group 1), drugs or v...
Source: Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
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Source: World Journal of Acupuncture Moxibustion - Category: Complementary Medicine Source Type: research
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Source: World Journal of Acupuncture Moxibustion - Category: Complementary Medicine Source Type: research
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Source: Journal of the Saudi Heart Association - Category: Cardiology Source Type: research
Publication date: Available online 17 July 2019Source: Global HeartAuthor(s): Jessica Ying-Yi Xie, Matthew R. Solomons, Mahmood Ahmad
Source: Global Heart - Category: Cardiology Source Type: research
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Source: American Heart Journal - Category: Cardiology Source Type: research
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Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
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Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
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Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
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Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
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