Endocannabinoids, stress signaling, and the locus coeruleus-norepinephrine system

Publication date: Available online 25 May 2019Source: Neurobiology of StressAuthor(s): Ryan R. Wyrofsky, Beverly A.S. Reyes, Xiao-Yan Zhang, Seema Bhatnagar, Lynn G. Kirby, Elisabeth J. Van BockstaeleAbstractThe endocannabinoid (eCB) system has been implicated in a variety of physiological functions due to abundant expression of its receptors and endogenous ligands in the central nervous system. Substantial progress has been made in understanding how the eCB system influences the brain norepinephrine (NE) system, an important neurochemical target in the continued development of new therapies for stress-induced psychiatric disorders. We, and others, have characterized the neuroanatomical, biochemical and pharmacological effects of cannabinoid receptor modulation on brain noradrenergic circuitry and defined how molecular elements of the eCB system are positioned to directly impact the locus coeruleus (LC)-prefrontal cortex pathway, a neural circuit well recognized for contributing to symptoms of hyperarousal, a key pathophysiological feature of stress-related disorders. We also described molecular and electrophysiological properties of LC noradrenergic neurons and NE release in the medial prefrontal cortex under conditions of cannabinoid type 1 receptor deletion. Finally, we identified how stress influences cannabinoid modulation of the coeruleo-cortical pathway. A number of significant findings emerged from these studies that will be summarized in the present review and have i...
Source: Neurobiology of Stress - Category: Neuroscience Source Type: research