Synthesis and stereochemistry assignment of (3R,5R)- and (3S,5R)-4-benzyl-3-(3,4-dimethoxyphenyl)-5-phenyl-1,4-oxazin-2-ones
Publication date: Available online 25 May 2019Source: Journal of Molecular StructureAuthor(s): Agnieszka Grajewska, Maria D. Rozwadowska, Andrzej GzellaAbstractThe diastereoselective synthesis of 3,5-disubstituted 1,4-oxazin-2-ones, the valuable intermediates on the route to tetrahydroisoquinoline derivatives, was based on the Petasis reaction in which (R)-(−)-N-benzyl-2-phenylglycinol was used as the amine component. It was demonstrated that the configuration of the newly generated C3 stereogenic centers in synthesized compounds, as well as in other 3,5-disubstituted 1,4-oxazin-2-ones, could be established simply by 1H NMR spectral data analysis. The absolute configuration of the major isomer was additionally confirmed by single crystal X-ray analysis.Graphical abstract
Obituary A Remembrance of Juan "Jay" Rodrigo MD (1943-2018). Clin Orthop Relat Res. 2019 Jul;477(7):1760-1761 Authors: Calabro A PMID: 31210645 [PubMed - in process]
Abstract BACKGROUND: Above-knee amputation (AKA) is a severe but rare complication of TKA. Recent evidence suggests there are sex and racial disparities with regard to AKA after TKA. However, whether lower socioeconomic status is associated with an increased risk of AKA after TKA has not been conclusively established. QUESTIONS/PURPOSES: (1) Is low socioeconomic status or use of public health insurance plans associated with an increased risk of AKA after periprosthetic joint infection (PJI) of the knee? (2) Is race or sex associated with an increased risk of AKA after PJI of the knee? METHODS: This cross...
Commonwealth Fund–supported researchers examined how insurance coverage and employment changed in the early aftermath of Arkansas’s Medicaid work requirements, reporting that in the first six months, the requirements resulted in a loss of health care coverage and failed to increase employment rates.
This year, 2019, has become a critical time for abortion rights, with an unprecedented surge of abortion bans sweeping across the United States.
Introduction Parental barriers are a key factor to determine physical activity behaviors, such as active commuting to school in young people. The purpose of this study was to test the reliability and validity of a questionnaire which addresses parental ba...
In Cambodia, motorcycle use has spread rapidly in recent years, and serious accidents involving motorcycles have increased. Motorcycle accidents involving young people are particularly common, and there are various issues concerning traffic safety. To unde...
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