Driving the point home: novel approaches to mitigate crash risk for patients with ADHD - Raman S, Engelhard M, Kollins SH.

Individuals diagnosed with attention-deficit/hyperactivity disorder (ADHD) across the life span are at significantly increased risk for a wide range of adverse outcomes, including substance use, obesity, and suicidal behavior. Risky driving, measured in...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

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ConclusionWe present a comprehensive mRNA expression profile of chromogranin A positive enteroendocrine cells following RYGB in rats. The data provides a region-specific characterization of all regulated preprohormone encoding genes in the rat GI tract including 16 not hitherto known. The comprehensive catalogue of preprohormone expression changes may support our understanding of hormone mediated effects of RYGB on diabetes remission and body weight reduction.Graphical abstract
Source: Peptides - Category: Biochemistry Source Type: research
ConclusionAcute organophosphate poisoning treated with atropine showed a potential for inducing prothrombotic coagulation abnormalities, presented with PT. This life-threatening complication may additionally contribute to prolonged morbidity and mortality in OP poisonings, especially in patients with medical history of comorbidites.
Source: Toxicology Reports - Category: Toxicology Source Type: research
Abstract The underlying molecular basis for neurodevelopmental or neuropsychiatric disorders is not known. In contrast, mechanistic understanding of other brain disorders including neurodegeneration has advanced considerably. Yet, these do not approach the knowledge accrued for many cancers with precision therapeutics acting on well-characterized targets. Although the identification of genes responsible for neurodevelopmental and neuropsychiatric disorders remains a major obstacle, the few causally associated genes are ripe for discovery by focusing efforts to dissect their mechanisms. Here, we make a case for del...
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Tags: CNS Neurosci Ther Source Type: research
"At Integrative NeuroTherapy, LLC ADHD is addressed using Neurofeedback and Functional Neurology methods that help identify disordered neural pathways, connections, and activity in the brain and throughout the body. This is accomplished using several analytical procedures including QEEG/brain mapping, evaluating certain types of eye movements, testing body coordination and movements, evaluating spinal and other reflexes, computerized testing of attention and impulsivity, biochemical analysis... ADHD and Brain Mapping
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Psychology [Psy.D. / Ph.D.] Source Type: forums
Publication date: Available online 15 June 2019Source: Science &SportsAuthor(s): J. Zhao, J. Shi, B. Wu, X. Bai, H. DuSummaryIntroductionThe aim of this study was to determine the effects of aerobic exercise on the alternative splicing of PKCδI pre-mRNA in obese mice.Summary of facts and resultsAfter aerobic exercise, the weight, the Lee's index and the blood lipid levels of obese mice decreased significantly (P 
Source: Science and Sports - Category: Sports Medicine Source Type: research
ConclusionThese findings indicate that the HFS Weanling group animals were better able to cope with the dietary challenge of an HFS diet than the HFS Adult group animals. Interestingly, when assessing various serum pro-inflammatory markers, no significant differences were detected between the HFS Adult and HFS Weanling groups. Although details regarding the mechanisms underlying an increase in knee joint damage scores in the HFS Adult group remain to be elucidated, these findings indicate that dietary exposure time maybe less important than the age at which a HFS diet is introduced. Moreover, increases in serum pro-inflamm...
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
CONCLUSIONS: Long-term associations of childhood ADHD with adverse physical health and socioeconomic outcomes underscore the need for early intervention. Young adult ADHD showed stronger associations with poorer mental health, substance misuse and psychosocial outcomes, emphasising the importance of identifying and treating adults with ADHD. The Study in Context: Neurofeedback or medication to treat ADHD? What are cognitive abilities and how to boost them? Rates of ADHD diagnosis and medication treatment continue to increase substantially
Source: SharpBrains - Category: Neuroscience Authors: Tags: Attention and ADD/ADHD Education & Lifelong Learning Health & Wellness ADHD symptopms attention deficit hyperactivity disorder Genetics mental health problems psychiatry Source Type: blogs
We describe the effects of LDX (50mg and 70mg) on the Sheehan Disability Scale (SDS; exploratory endpoint) from both studies. Design: The SDS was assessed at baseline, Week 6, and Week 12/early termination. Analyses included mixed-effects models for repeated measures for the examination of SDS total and domain score changes and a generalized estimating equation model to assess dichotomized remission status (remission [total score ?6] versus nonremission [total score>6]). Results: Least squares (95% confidence interval [CI]) mean treatment differences for SDS total score change from baseline at Week 12 were -2.80 (-3.98,...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Drug Development Original Research binge eating disorder disability functionality lisdexamfetamine dimesylate Sheehan Disability Scale Source Type: research
Conclusions: This article provides recommendations for researchers and federal funders to ensure respect for the contributions of TEK to research and to ensure equity and self-determination for Tribal nations who participate in research. https://doi.org/10.1289/EHP858 Received: 22 July 2016 Revised: 10 April 2017 Accepted: 27 April 2017 Published: 29 August 2017 Address correspondence to S. Finn, National Institute of Environmental Health Sciences, Division of Extramural Research and Training, Population Health Branch, 530 Davis Drive, Durham, NC 27713 USA. Telephone: 919-541-4258. Email: finns@niehs.nih.gov The auth...
Source: EHP Research - Category: Environmental Health Authors: Tags: Commentary Source Type: research
CASE: Alex is a 13-year-old adolescent with high-functioning autism spectrum disorder, attention-deficit/hyperactivity disorder (ADHD)-combined type, anxiety, and depression. He has been resistant to engaging in therapy and treatment with various medications has been unsuccessful. Alex's parents are concerned about his anxiety, isolation, oppositional behaviors, academic underachievement, truancy, and substance use. A recent altercation with his stepfather led to a police intervention and a brief removal of Alex from the home. Alex previously used alcohol and other drugs; at present, he reports that his current drug use co...
Source: Journal of Developmental and Behavioral Pediatrics - Category: Child Development Tags: Challenging Case Source Type: research
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