Biomarkers help tailor diuretic use in acute heart failure patients

(European Society of Cardiology) Adrenomedullin activity predicts which acute heart failure patients are at the greatest risk of death without diuretic treatment post-discharge, according to late breaking research presented today at Heart Failure 2019, a scientific congress of the European Society of Cardiology (ESC).'Therapy at discharge often remains unchanged for several weeks and even months in acute heart failure patients,' said first author Dr Nikola Kozhuharov, of the University Hospital Basel, Switzerland.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

Related Links:

ConclusionsRisk stratification for cardiac amyloidosis with the newly developed “HeiRisk” score may be superior to other staging systems for patients with advanced heart failure due to amyloid cardiomyopathy.
Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research
Transthyretin amyloidosis can be either the wild-type (ATTR-wt) or the hereditary form (ATTR-m) with autosomal dominant inheritance. ATTR seems to be an underdiagnosed disease, despite now being recognized as one of the most frequent causes of heart failure (HF) with preserved ejection fraction. The confirmation of diagnosis includes a genetic analysis as a critical step to distinguish between ATTR-wt and hereditary amyloidosis. The present study aimed to evaluate the potential application of High-Resolution Melting (HRM) analysis for identifying gene mutations in patients with suspected ATTR-m.
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Renal dysfunction is a harbinger of poor prognosis in heart failure (HF),1 portending a greater risk of death than the degree of left ventricular dysfunction or New York Heart Association functional class.2 Deranged renal function is not only a marker of illness severity; it may independently hasten the progression of heart failure by accelerating maladaptive physiological pathways1,2 while decreasing the likelihood that patients will receive optimal medical therapy for heart failure.3 This is particularly germane to patients hospitalized with acutely decompensated heart failure (ADHF), the majority of whom present with ab...
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: Brief Report Source Type: research
FRIDAY, Oct. 18, 2019 -- For Asian patients with heart failure, those who are lean-fat with a high waist-to-height ratio (WHtR) and low body mass index (BMI) have the worst outcomes, according to a study published online Sept. 24 in PLOS...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
In this study, we aimed to evaluate the differential impact of DM2 on all-cause mortality in men vs women with HFpEF after admission for acute HF.MethodsWe prospectively included 1019 consecutive HFpEF patients discharged after admission for acute HF in a single tertiary referral hospital. Multivariate Cox regression analysis was used to evaluate the interaction between sex and DM2 regarding the risk of long-term all-cause mortality. Risk estimates were calculated as hazard ratios (HR).ResultsThe mean age of the cohort was 75.6 ± 9.5 years and 609 (59.8%) were women. The proportion of DM2 was similar betwe...
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
ConclusionsThe results of the BRAKE-AF project might allow inclusion of ivabradine within the limited arsenal of drugs currently available for rate control in AF.Clinical trial registration: http://www.clinicaltrials.gov. Identifier: NCT03718273.ResumenIntroducción y objetivosLa ivabradina es un inhibidor de la corriente If, principal determinante de la función marcapasos del nódulo sinusal, aprobado como antianginoso y para tratar la insuficiencia cardiaca. Existen indicios sobre su capacidad para inhibir la conducción a través del nódulo auriculoventricular (NAV). Sobre esta base...
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
Publication date: Available online 16 October 2019Source: Canadian Journal of CardiologyAuthor(s): Sattler Katherine, El-Battrawy Ibrahim, Gietzen Thorsten, Kummer Marvin, Lang Siegfried, Zhou Xiao-bo, Behnes Michael, Borggrefe Martin, Akin IbrahimAbstractBackgroundCardiogenic shock (1) is a severe complication of myocardial infarction (MI) or of takotsubo syndrome. For both diseases, CS is related to a worse long term outcome. Outcome of CS has not been studied in a direct comparison of MI patients and TTS patients.Methods and ResultsMortality and cardiovascular complications were compared in patients presenting with CS b...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Authors: Lee SH, Hon KL, Chiu WK, Ting YW, Lam SY Abstract OBJECTIVES: There is no guideline in Hong Kong regarding respiratory syncytial virus (RSV) immunoprophylaxis for children with heart disease because of a lack of local data on RSV infection. Therefore, this study evaluated the epidemiology and impact of RSV infection on children with heart disease in Hong Kong, with the goal of providing recommendations regarding RSV immunoprophylaxis. METHODS: This multicentre retrospective case-control study on paediatric RSV infection was conducted in four local regional hospitals from 2013 to 2015. The patients' dem...
Source: Hong Kong Medical Journal - Category: General Medicine Tags: Hong Kong Med J Source Type: research
Abstract PURPOSE: To investigate the effect of tanshinone IIA (TIIA) on ventricular remodeling in rats with pressure overload-induced heart failure. METHODS: Pressure overload-induced heart failure model (abdominal aortic coarctation) was established in 40 rats, which were divided into model and 5, 10 and 20 mg/kg TIIA groups. Ten rats receiving laparotomy excepting abdominal aortic coarctation were enrolled in sham-operated group. The 5, 10 and 20 mg/kg TIIA groups were treated with 5, 10 and 20 mg/kg TIIA, respectively, for 8 weeks. RESULTS: Compared with model group, in 20 mg/kg TIIA group the left ve...
Source: Acta Cirurgica Brasileira - Category: Surgery Authors: Tags: Acta Cir Bras Source Type: research
Contributors : Yuto Nakamura ; Shunbun Kita ; Yoshimitsu Tanaka ; Shiro Fukuda ; Yoshinari Obata ; Tomonori Okita ; Yusuke Kawachi ; Yuri Shimizu-Tsugawa ; Yuya Fujishima ; Hitoshi Nishizawa ; Atusko Sehara ; Norikazu Maeda ; Iichiro ShimomuraSeries Type : Expression profiling by arrayOrganism : Mus musculusTo investigated global changes caused by pressure overload-induced heart failure in ADAM12 knockout mice using a microarray analysis.A disintegrin and metalloproteinase (ADAM) 12 is has long been considered to promote cardiac dysfunction based on according to the finding report that a small molecule ADAM12 inhibitor, KB...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
More News: Cardiology | Heart | Heart Failure | Hospitals | International Medicine & Public Health | Politics | Switzerland Health