Direct oral anticoagulants are associated with limited damage of endothelial cells of the blood-brain barrier mediated by the thrombin/PAR-1 pathway.

In conclusion, DOACs seem to limit the alteration of the monolayer of endothelial cells of the BBB mediated by the thrombin/PAR-1 pathway. PMID: 31121158 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31121158?dopt=Abstract

Source: Brain Research - May 19, 2019 Category: Neurology Authors: Puech C, Delavenne X, He Z, Forest V, Mismetti P, Perek N Tags: Brain Res Source Type: research