Superior perioperative outcomes with direct anterior approach total hip arthroplasty in a Veteran's affairs patient population
ConclusionAmong veterans undergoing primary THA at a VA hospital, patients undergoing DAA THA had better perioperative outcomes than patients treated with the posterior approach despite similar demographics, American Society of Anesthesiologists score, and the DAA learning curve.
Publication date: Available online 26 February 2020Source: Current Therapeutic ResearchAuthor(s): Patrice Vincent, Thibaut Lucas de Couville, Thierry Thomas
ConclusionsThe association of rs4867568 and rs143383 with KOA was successfully replicated in the Chinese Han population. Moreover, rs4867568 was found significantly associated with the severity of KOA. More studies are warranted to explore the functional role of rs4867568 in the development of KOA.Key Points• A novel variant near Lsp1p3 is associated with knee osteoarthritis.• Baseline characteristics of the subjects.• Comparison of the genotype and allele frequency of the Lsp1p3, GDF5, and FTO.• Association of the Lsp1p3, GDF5, and FTO with KOA severity.
Publication date: Available online 25 February 2020Source: European Journal of Integrative MedicineAuthor(s): Mitra Abbasifard, Rahele Zareshahi
Conditions: Rotator Cuff Tear Arthropathy; Shoulder Osteoarthritis Intervention: Behavioral: Patient-led rehab with short immobilization Sponsors: University of Missouri-Columbia; Harry S. Truman Memorial Veterans Hospital Not yet recruiting
AbstractBackgroundOsteoarthritis (OA) is a degenerative chronic illness that most frequently occurs in the knee joint. Daidzein (DZ) an isoflavone has anti-inflammatory and antioxidant activity. The aim of this study was to evaluate the effectiveness of DZ as a treatment for experimental knee OA (KOA) in rats.MethodAn experimental KOA model was induced by monosodium iodoacetate (MIA) in rats. Thereafter, 49 Wistar albino male rats (250 –300 g, 12–16 weeks old) were randomly divided into 7 groups: C (healthy control); DC (KOA + saline); hyaluronic acid (HA); HA+ intraarticular (ia) DZ; oral (po) DZ; ia...
Osteoarthritis (OA) is a chronic degenerative disease wherein the articular cartilage exhibits inflammation and degradation. Scutellarin (SCU) is a flavonoid glycoside with a range of pharmacological activities, as shown in previous studies demonstrating its anti-inflammatory activity. How SCU impacts the progression of OA, however, has not been explored to date. Herein, we assessed the impact of SCU on murine chondrocytes in an OA model system. In in vitro assays, we measured chondrocyte expression of key OA-associated factors such as matrix metalloproteinase 13 (MMP-13), a disintegrin and metalloproteinase with thrombosp...
Publication date: March–April 2020Source: The Journal of Foot and Ankle Surgery, Volume 59, Issue 2Author(s): Takumi Matsumoto, Taro Kasai, Akihiro Uchio, Naohiro Izawa, Juji Takuo, Sakae Tanaka
This study investigated 43 ankles in 41 patients who underwent ankle arthrodesis at 1 of the 2 study institutions. There were 15 men and 26 women, and their mean age was 66.2 (range 49 to 87) years. The primary disease included osteoarthritis (OA) (79%), rheumatoid arthritis (RA) (16.3%), and Charcot joint (4.7%).
We report 3 cases of excision arthroplasty with interpositional Achilles tendon autograft for the treatment of end-stage talonavicular osteoarthritis in low-demand elderly patients.
An investigational selective cathepsin K inhibitor called MIV-711 failed to decrease knee osteoarthritis pain but attenuated bone area progression and reduced cartilage volume loss, a multicenter European trial reported in the Annals of Internal Medicine.