An Outbreak of MRSA colonisation in a Neonatal intensive care unit: use of a case control study to investigate and control it and lessons learned

We describe the investigation and management of an MRSA outbreak on a neonatal intensive care unit (NICU) and the lessons learnt.Study designOutbreak report and case-control study.Study setting and participants: The study was conducted in a 40-cot NICU in a tertiary referral hospital and included all infants colonised/infected with gentamicin-resistant MRSA.InterventionsStandard infection control measures including segregation of infants, barrier precautions, enhanced cleaning, assessment of staff practice including hand hygiene, and increased MRSA screening of infants were implemented. Continued MRSA acquisitions led to screening of all NICU staff. A case-control study was performed to assess staff contact with colonised babies and inform the management of the outbreak.ResultsEight infants were colonised with MRSA (spa type t2068), one of whom subsequently developed an MRSA bacteraemia. MRSA colonisation was significantly associated with lower gestational age; lower birthweight and with being a twin. Three nurses were MRSA colonised but only nurse 45 was colonised with MRSA spa type t2068. Multivariable logistic regression analysis identified being cared for by nurse 45 as an independent risk factor for MRSA colonisation.InterpretationLack of accurate recording of which nurses looked after which infants (and when) made identification of the risk posed by being cared for by particular nurses difficult. If this had been clearer, it may have enabled earlier identification of th...
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research

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Abstract To study pathogenesis and toxicity of Staphylococcus aureus in foods, FORC_062 was isolated from a human blood sample and complete genome sequence has a type II SCCmec gene cluster and a type II toxin-antitoxin system, indicating an MRSA strain. Its mobile gene elements has many pathogenic genes involved in host infection, biofilm formation, and various enterotoxin and hemolysin genes. Clinical MRSA is often found in animal foods and ingestion of MRSA-contaminated foods causes human infection. Therefore, it is very important to understand the role of contaminated foods. To elucidate the interaction betwee...
Source: Food Microbiology - Category: Food Science Authors: Tags: Food Microbiol Source Type: research
ConclusionOur results reveal the radiation of distinct lineages of MRSA ST228 from a German progenitor, as the clone spread into different European countries. In Switzerland, ST228 was introduced first in Geneva and was subsequently introduced into Lausanne.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Staphylococcus aureus is a leading cause for clinical infections and food intoxications, causing over 100,000 yearly cases of bacteremia in the United States and 434 food-borne outbreaks in the European Union. Approximately 30% of the population permanently carry S. aureus asymptomatically in their nasal cavity. The risk of infection and transmission to food items or the environment is higher in individuals that are nasally colonized. In addition, S. aureus can acquire various antimicrobial resistances leading to therapeutic failure, additional medical costs, and fatalities. Methicillin-resistant S. aureus (MRSA) cause a c...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
When Vanessa is asked to clean up after patients who have the seasonal flu or measles or MRSA in the Pennsylvania hospital where she works in environmental services, she knows what to do. She knows how to disinfect surfaces, what needs to be thrown away and what she should wear to protect herself. But when she’s asked to clean rooms occupied by COVID-19 patients, she’s flying blind. “It’s kind of terrifying,” says Vanessa, who TIME is identifying by first name only for professional protection. Her supervisors told her to clean the rooms just as she would for a flu patient, but she says she&rsq...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
CONCLUSIONS: Although MRSA has a low prevalence in our center, a variation in the rate of MRSA positivity was observed across patients from different countries. Absence hospital acquired contamination or outbreaks in our institution may be attributed to the screening algorithm used and underscores the importance of risk analysis for patients referred from geographical locations with unknown MRSA frequency, to reduce the risk of transmission. PMID: 32160784 [PubMed - as supplied by publisher]
Source: Acta Microbiologica et Immunologica Hungarica - Category: Microbiology Authors: Tags: Acta Microbiol Immunol Hung Source Type: research
This article summarizes the available evidence enabling a stratification of risk for multidrug-resistant bacteria (MDRB) in patients with skin and soft tissue infection (SSTI). Recent findings MDRB are increasingly reported in both healthcare-associated (HCA) and community-acquired (CA)-SSTI, including in patients with life-threatening presentations for whom early initiation of adequate antimicrobial therapy is pivotal to improve outcomes. Community-associated methicillin-resistant Staphylococcus aureus (MRSA) is now endemic in several geographical areas and may cause outbreaks in frail populations or other at-risk clus...
Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: SKIN AND SOFT TISSUE INFECTIONS: Edited by Matteo Bassetti Source Type: research
Publication date: Available online 19 February 2020Source: Artificial Intelligence in MedicineAuthor(s): Fernando Jiménez, José Palma, Gracia Sánchez, David Marín, Francisco Palacios, M.D, Lucía López, M.DAbstractAntimicrobial resistance has become one of the most important health problems and global action plans have been proposed globally. Prevention plays a key role in these actions plan and, in this context, we propose the use of Artificial Intelligence, specifically Time Series Forecasting techniques, for predicting future outbreaks of Methicilin-resistant Staphylococcus aereu...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
Pandemics are perversely democratic. They’re nasty, lethal and sneaky, but they don’t discriminate. No matter your age, ethnicity, religion, gender, or nation, you’re a part of the pathogenic constituency. That shared vulnerability, and the resulting human collectivism—a universal response to a universal threat—is newly and vividly evident in the face of the now-global outbreak of the novel coronavirus known as 2019-nCoV. As of writing, there have been over 30,000 diagnosed cases and over 630 related deaths. A virus that emerged in a single city, Wuhan, China—indeed, in a single crowded ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized 2019-nCoV Infectious Disease Source Type: news
ConclusionsSurveillance aids in early detection and successful control of outbreaks. A systematic search for the source and meticulous containment of spread can successfully control an outbreak.
Source: Indian Journal of Pediatrics - Category: Pediatrics Source Type: research
(CNN) — The US Food and Drug Administration is giving the maker of Purell products a stern warning: Stop making unproven claims that over-the-counter hand sanitizers help eliminate Ebola, MRSA or the flu. In a “warning letter” to Purell’s parent, Gojo Industries, the agency called out the company for making numerous marketing claims that potentially position its sanitizing products as a pharmaceutical drug rather than an over-the-counter topical antiseptic. The letter from the agency’s director of compliance cited numerous examples of what the FDA says are unproven claims for Purell products m...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Syndicated CBSN Boston CNN Hand Sanitizer Source Type: news
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