On-label compared to off-label four-factor prothrombin complex concentrate use: a retrospective, observational study.

CONCLUSION: 4F-PCC is an effective but expensive treatment option for those requiring urgent reversal of vitamin K antagonist-induced coagulopathy. However, providers should be conscious of the high costs and questionable efficacy when using 4F-PCC off-label. PMID: 31121073 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31121073?dopt=Abstract

Source: Transfusion - May 22, 2019 Category: Hematology Authors: Cho BC, Jung YH, DeMario VM, Lau E, Podlasek SJ, Grant MC, Gehrie EA, Frank SM Tags: Transfusion Source Type: research