A Review of Cutaneous Microdialysis of Inflammatory Dermatoses.

A Review of Cutaneous Microdialysis of Inflammatory Dermatoses. Acta Derm Venereol. 2019 May 23;: Authors: Rea H, Kirby B Abstract Microdialysis is a minimally invasive technique to study metabolic, biochemical, and pharmacological events in tissue. Factors that influence microdialyslate collection include molecular weight cutoff of the membrane, perfusion rate, perfusate viscosity, duration of collection, depth of the catheter, length of the tubing and adsorption of hydrophobic molecules to the membrane. To standardize these factors, a robust sampling protocol needs to be established. Microdialysis is applied in healthy and inflamed skin. It enables the in vivo sampling of endogenous and exogenous substances in skin's extracellular fluid. In atopic dermatitis, levels of neuropeptides, eicosanoids and histamine pre- and post-treatment treatment have been conducted. Microdialysis in atopic skin has assessed the pharmodynamics of a number of topical drugs. In psoriatic skin, the 'cytokine fingerprint' has been evaluated through microdialysis and bioassays. This unique fingerprint has also been analyzed after certain pharmacological treatments for psoriasis. PMID: 31120543 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research

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Purpose of review Several chronic inflammatory skin disorders have been linked to metabolic syndrome (MetS) and an increased risk for cardiovascular disease. In this review, we will summarize the recent evidence on the association between psoriasis, hidradenitis suppurativa (HS), and atopic dermatitis (AD) and metabolic syndrome with careful attention to this association among the pediatric population. Recent findings Historically, psoriasis has exhibited the most robust association with MetS in the literature. Recent studies show that the prevalence of MetS appears to be higher among patients with HS and can be assoc...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: GENETICS OF VASCULAR MALFORMATION AND THERAPEUTIC IMPLICATIONS: Edited by Joyce M.C. Teng Source Type: research
This case report describes a series of patients who developed eczema after being treated for psoriasis with secukinumab.
Source: JAMA Dermatology - Category: Dermatology Source Type: research
ConclusionWBR is effective in the imiquimod-induced psoriasis-like inflammation mouse model with the efficacy arising from its proliferation inhibition of Th1/Th17 cells and epidermal keratinocytes via the down-regulation of the relevant inflammatory cytokines such as IL-23, IL-17A, and IL-17F. Collectively, WBR harvested and processed in the traditional manner is an efficacious psoriasis-treating agent.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion: This study showed that hair loss in children in our region is not an uncommon problem and results from a variety of causes. Early diagnosis and treatment are needed to prevent further hair loss and to avoid irreversible hair loss and scarring alopecia. As has been observed in this study, hair problem may be due to important nutritional deficiency. We should be aware of such presentation. These may be a clue to the diagnosis of systemic illness.
Source: Indian Journal of Dermatology - Category: Dermatology Authors: Source Type: research
This article aims to present a basic introduction to the concepts of artificial intelligence as well as  present an overview of the current research into artificial intelligence in dermatology, examining both its current applications and its future potential.
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research
This article is protected by copyright. All rights reserved. PMID: 31269228 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
Discussion Atopic dermatitis (AD) has a prevalence of 3-5% in the overall U.S. population but is increasing with an estimated 10-15% lifetime risk in childhood. It is even more common in children of color with a prevalence in African-American/black children of 17% and Hispanic children of 14%. Health care utilization data also appears to support more severe disease in children of color also. Atopic dermatitis or eczema is a common dermatological skin problem which characteristically is a pruritic, papular eruption with erythema. Like most papulosquamous eruptions it often occurs in intertrigenous areas in people with alle...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
CONCLUSION: The ensemble method used on Dermatology datasets give better performance as compared todifferent classifier algorithms. Ensemble method gives more accurate and effective skin disease prediction. PMID: 31244314 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
Pruritus in autoimmune and inflammatory dermatoses is a common symptom that can be severe and affect the quality of life of patients. In some diseases, itch is related to disorders activity and severity or may occur independent of the disease. Despite the high prevalence, the symptom is still underrated and there are only a few trials investigating the efficacy of drugs for disease-specific pruritus. In this review, the characteristics and possible pathomechanisms of pruritus in various dermatoses like bullous autoimmune diseases, connective tissue diseases as well as autoimmune-associated dermatoses (atopic dermatitis, ps...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Several lines of evidence indicate that the immune system, inflammation and coagulation are simultaneously activated in autoimmune and immune-mediated skin diseases. Proinflammatory cytokines such as interleukin-6 and tumor necrosis factor-alpha induce the expression of the main initiator of coagulation, i.e. tissue factor. The proteases of coagulation in turn act on protease-activated receptors inducing the expression of various proinflammatory cytokines triggering inflammation. The cross-talk among immune system, inflammation and coagulation amplifies and maintains the activation of all three pathways. This review focuse...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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