Stimulating Science: One Year After the Recovery Act

A year ago, as the US economy was on the brink of meltdown, Congress and President Obama enacted the American Recovery and Reinvestment Act of 2009 (ARRA; PL 111-5). The $787-billion economic stimulus promised a new future for America, a future that not only brought economic growth and jobs but also addressed society's most pressing issues: education, human health, infrastructure, and clean energy. The act included more than $24 billion for federal science programs, much of which was designated for research and development (R&D). These funds were intended to create or save jobs by directly supporting researchers and student fellows and spurring the manufacturing of scientific instrumentation and equipment, as well as initiating the repair and construction of research facilities. One year later, stimulus funds have been used to address a backlog of scientific needs and to usher in a new age of science. The question now, however, is: What will happen to our scientific enterprise in 2011, when the ARRA funds have been spent? The stimulus outlined ambitious goals for federal science agencies. The National Science Foundation (NSF) aimed to support 40,000 researchers, educators, postdoctoral scholars, and students with its $3 billion of ARRA funding, including $2 billion for "high-risk, potentially transformative research proposals" that were already in hand. The National Institutes of Health (NIH) planned to create or save 50,000 jobs with its $10.4 billion in ARRA funds...
Source: Washington Watch - Category: Biology Authors: Source Type: news

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This article aimed to investigate effects of exosomes secreted from miRNA-29b-modified bone marrow mesenchymal stem cells (BMSCs) on SCI. Exosomes were extracted from BMSCs transfected with miRNA-29b or negative control (miR NC). SCI rats were injected intravenously with exosomes (control exosomes, miRNA-29b exosomes) and BMSCs (miR NC, miRNA-29b) through the tail vein. The expression of miRNA-29b in spinal cord tissues of SCI rats was detected by qRT-PCR. The hind limb motor function was evaluated by Basso Beattie Bresnahan (BBB) score. The histopathological damage and neuronal regeneration in spinal cord tissues was obse...
Source: Braz J Med Biol Res - Category: Research Authors: Tags: Braz J Med Biol Res Source Type: research
Publication date: December 2019Source: British Journal of Oral and Maxillofacial Surgery, Volume 57, Issue 10Author(s): James Fitton, Alice Cameron, Richie Gill, Serryth Colbert
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: December 2019Source: British Journal of Oral and Maxillofacial Surgery, Volume 57, Issue 10Author(s): Alexander Hills, Brian Bisase, Paul Norris, Karan Kapoor, Mike Shelley, Charles Nduka, Ruben Kannan
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
ConclusionFailure of TVr in this cohort occurred at a significant rate. Failure of TVr is an independent risk factor for development of late RHF. Future studies should investigate strategies to reduce recurrence of significant TR.Central Illustration
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
In this study, we have synthesized a novel composite hydrogel formed by crosslinking between bioactive glass and PVA for cartilage repair, furthermore, we have explored the reaction mechanism of this hydrogel. It was found that hydrogen bonding was formed by the hydroxyl groups in PVA combining with the oxygen atoms from the non-bridge Si-O bond in bioactive glass, which can explain better mechanical properties for PM group than that of PVA. The tensile and compressive stress of PM5 hydrogel group has reached 4.8 MPa and 1.8 MPa equaling mechanical properties of natural articular cartilage. Moreover, the hydrogel can s...
Source: Journal of Non Crystalline Solids - Category: Chemistry Source Type: research
Conclusion: Microsurgical treatment is an effective method for VA and PICA aneurysms. The majority of VA and PICA aneurysms do not require complex basal approaches. A thorough preoperative planning, reconstructive clipping techniques, and anastomoses creation, as well as patient selection based on the established algorithms and consultations with endovascular surgeons, may reduce the number of complications and increase the rate of complete microsurgical occlusion in VA and PICA aneurysms. PMID: 31819820 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Authors: Parmar A, Chan KKW, Ko YJ Abstract Therapeutic options for chemorefractory metastatic colorectal cancer (mcrc) have significantly expanded since 2009. The oral targeted therapies regorafenib and trifluridine/tipiracil have been established to be efficacious and safe in patients with mcrc who have progressed beyond 2 or more lines of chemotherapy. Evidence for the use of immunotherapy in a subgroup of this patient population is also encouraging, particularly in patients with mcrc that exhibits high microsatellite instability or deficient mismatch repair. Those significant advances have led to Health Canada ...
Source: Current Oncology - Category: Cancer & Oncology Tags: Curr Oncol Source Type: research
Discussion: This review is split into two sections. In the first section, we review the prognostic and predictive significance of expanded RAS mutation testing, BRAF mutations, ERBB2 (her2) amplification, microsatellite instability (msi) and deficient mismatch repair (dmmr) protein, NTRK fusions, PIK3CA mutations, and met amplifications. The therapeutic implication of each of those biomarkers for personalizing therapies for each patient with mcrc is discussed. In the second section, we touch on testing methods and considerations of relevance to clinicians when they interpret companion diagnostics meant to guide therapy sel...
Source: Current Oncology - Category: Cancer & Oncology Tags: Curr Oncol Source Type: research
Publication date: Available online 11 December 2019Source: Pharmacology &TherapeuticsAuthor(s): Alice Bradbury, Sally Hall, Nicola Curtin, Yvette DrewAbstractThe DNA damage response (DDR) machinery is responsible for detecting DNA damage, pausing the cell cycle and initiating DNA repair. Ataxia telangiectasia and Rad3-related (ATR) protein is a key kinase at the heart of the DDR, responsible for sensing replication stress (RS) and signalling it to S and G2/M checkpoints to facilitate repair. In cancer, loss of G1 checkpoint control and activation of oncogenes that drive replication, result in cancer cells more likely t...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 11 December 2019Source: Pharmacology &TherapeuticsAuthor(s): Yinglu Guan, Guan Wang, Danielle Fails, Priyadharsini Nagarajan, Yejing GeAbstractCancer hijacks embryonic development and adult wound repair mechanisms to fuel malignancy. Cancer frequently originates from de-regulated adult stem cells or progenitors, which are otherwise essential units for postnatal tissue remodeling and repair. Cancer genomics studies have revealed convergence of multiple cancers across organ sites, including squamous cell carcinomas (SCCs), a common group of cancers arising from the head and neck, esopha...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
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