Anopheles aquasalis transcriptome reveals autophagic responses to Plasmodium vivax midgut invasion

Elimination of malaria depends on mastering transmission and understanding the biological basis of Plasmodium infection in the vector. The first mosquito organ to interact with the parasite is the midgut and its ...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research

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Publication date: Available online 19 July 2019Source: Veterinary ParasitologyAuthor(s): Mohamed Abdo Rizk, Shimaa Abd El-Salam El-Sayed, Sabry El-Khodery, Naoaki Yokoyama, Ikuo IgarashiAbstractThere is an innovative approach to discovering and developing novel potent and safe anti-Babesia and anti-Theileria agents for the control of animal piroplasmosis. Large-scale screening of 400 compounds from a Malaria Box (a treasure trove of 400 diverse compounds with antimalarial activity has been established by Medicines for Malaria Venture) against the in vitro growth of bovine Babesia and equine Babesia and Theileria parasites ...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
Nature, Published online: 19 July 2019; doi:10.1038/d41586-019-02203-5A one-two punch knocks out treatment-resistant strains of malaria.
Source: Nature AOP - Category: Research Source Type: research
Conclusions. Plasmodium falciparum malaria was characterized by depression of cellular and humoral immunity, the degree of which depended on the severity of the pathological process. PMID: 31308850 [PubMed]
Source: Journal of Tropical Medicine - Category: Tropical Medicine Tags: J Trop Med Source Type: research
by Kit Kennedy, Simon A. Cobbold, Eric Hanssen, Jakob Birnbaum, Natalie J. Spillman, Emma McHugh, Hannah Brown, Leann Tilley, Tobias Spielmann, Malcolm J. McConville, Stuart A. Ralph Apicomplexan parasites possess a plastid organelle called the apicoplast. Inhibitors that selectively target apicoplast housekeeping functions, including DNA replication and protein translation, are lethal for the parasite, and several (doxycycline, clindamycin, and azithromycin) are in clinical u se as antimalarials. A major limitation of such drugs is that treated parasites only arrest one intraerythrocytic development cycle (approximately ...
Source: PLoS Biology: Archived Table of Contents - Category: Biology Authors: Source Type: research
This study enhances our understanding of how gut bacteria influence mosquito-Plasmodium interactions.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Contributors : Gabrielle A Josling ; Timothy J Russell ; Jarrett Venezia ; Lindsey Orchard ; Heather Painter ; Manuel Llin ásSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Plasmodium falciparumIn the malaria parasite Plasmodium falciparum, the switch from asexual multiplication to sexual differentiation into gametocytes is essential for transmission to mosquitos. One of the key determinants of sexual commitment is the transcription factor PfAP2-G, which has been proposed to orchestrate this crucial cell fate decision by driving expression of gametocyte genes. Here we identif...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Plasmodium falciparum Source Type: research
The importance of submicroscopic malaria infections in high-transmission areas could contribute to maintain the parasite cycle. Regarding non-endemic areas, its importance remains barely understood because par...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
Anopheles maculatus (s.s.) is an important vector of malaria in Indonesia. Previously it was considered the only member of the Maculatus Group present in Indonesia. A novel species was recently identified in the ...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
Abstract BACKGROUND: Drug efficacy trials monitor the continued efficacy of front-line drugs against falciparum malaria. Over-estimates of efficacy result in a country retaining a failing drug as first-line treatment with associated increases in morbidity and mortality, while under-estimating drug effectiveness leads to removal of an effective treatment with substantial practical and economic implications. Trials are challenging: they require long durations of follow-up to detect drug failures, and patients are frequently re-infected during that period. Molecular correction based on parasite genotypes distinguishe...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Authors: LoVerde PT Abstract Schistosomiasis is a major cause of morbidity in the world; it is second only to malaria as a major infectious disease. Globally, it is estimated that the disease affects over 250 million people in 78 countries of the world and is responsible for some 280,000 deaths each year. The three major schistosomes infecting humans are Schistosoma mansoni, S. japonicum, and S. haematobium. This chapter covers a wide range of aspects of schistosomiasis, including basic biology of the parasites, epidemiology, immunopathology, treatment, control, vaccines, and genomics/proteomics. In this chapt...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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