Gene Expression Profiling and Racial Disparities in Outcomes after Heart Transplantation
African Americans (AA) have reduced survival compared to Caucasians after heart transplantation (HTx).
Consistent achievement of life-supporting cardiac xenograft function in a preclinical model is the benchmark established by an International Society for Heart and Lung Transplantation expert advisory panel in 2000 as a precondition for clinical translation.1 This long-elusive goal appears to be close at hand based on a recent report by L ängin and colleagues,1 published late last year in Nature.2 The Munich-based team reported that 4 of 5 consecutive baboon recipients of orthotopically implanted genetically modified pig hearts survived beyond 90 days.
This study aimed to investigate whether FCGR2A and FCGR3A polymorphisms can also be associated with the clinical outcome of lung transplant recipients (LTRs). The SNPs of FCGR2A ([131R/H], rs1801274) and FCGR3A ([158V/F], rs396991) were identified in 158 LTx recipients (LTR) and 184 Controls (CTL). The corresponding distribution of genotypic and allelic combinations was analyzed for potential links with the development of circulating donor-specific anti-HLA alloantibodies (DSA) detected at months 1 and 3 after lung transplant (LTx), the occurrence of acute rejection (AR) and chronic lung allograft dysfunction (CLAD), and...
Sunday: Heart transplant Monday: Combined double lung and liver transplant Tuesday and Wednesday: One 12-hour left ventricular assist device procedure each day Thursday: Two lung transplants and a heart transplant Friday: Lung transplant What you're reading is the surgical schedule of the cardiothoracic transplant team at Mayo Clinic's Rochester campus for one week in May. [...]
Publication date: Available online 8 June 2019Source: Revista Española de Cardiología (English Edition)Author(s): María Lozano-Balseiro, Isaac Martínez-Bendayán, Oscar Pato-López, Mercedes De la Torre-Bravos, Francis Fynn-Thompson, Víctor Bautista-Hernández
In the early 19th century, the German scientist and poet Johann Wolfgang von Goethe published his celebrated drama entitled Faust, A Tragedy. In this drama, Faust, frustrated by his inability to gain infinite knowledge, strikes a deal with the demon, Mephistopheles. In doing so, while Faust is pursuing his ambitions, tragedy befalls his beloved ones, which leaves him unfulfilled. Such a Faustian bargain is an example of intended good that results in less ideal outcomes.
DISCUSSION: Passenger lymphocyte syndrome after mismatched organ transplantation is not rare, but the syndrome associated with non-ABO antibodies occurs in a much smaller subset of these cases. The mixtures of organ donor, recipient, and other transfused red blood cells profoundly limit the usefulness of serological testing. Genetic assignment of minor blood types to donor and recipient can guide therapy and inform prognosis. PMID: 31184578 [PubMed - as supplied by publisher]
Organ transplantation as an option to overcome end-stage diseases is common in countries with advanced healthcare systems and is increasingly provided in emerging and developing countries. A review of the literature points to sex- and gender-based inequity in the field with differences reported at each step of the transplant process, including access to a transplantation waiting list, access to transplantation once waitlisted, as well as outcome after transplantation. In this review, we summarize the data regarding sex- and gender-based disparity in adult and pediatric kidney, liver, lung, heart, and hematopoietic stem cel...
Lung transplant recipients (LTRs) have a high risk of developing Clostridium difficile infection (CDI), which can affect both graft and patient survival. Modalities to prevent post-transplant CDI are needed. We hypothesized that primary prophylaxis with oral vancomycin would be an effective preventive strategy. We assessed the association between oral vancomycin primary prophylaxis and CDI incidence by comparing the incidence rate of CDI in LTRs administered prophylaxis with that of LTRs given no prophylaxis.
In a previous issue of the journal, Apostolo et al.1 report on the impact of left ventricular support device (LVAD) speed change on several physiologic parameters, including maximal and sub-maximal exercise performance, sleep disordered breathing, and alveoli gas exchange. The patients were supported by the Jarvik device (Jarvik Heart, Inc., New York, NY), a unique chronic LVAD that permits patients to modify speed to meet work demands. The investigators used a variety of methodologies from several protocols to assess the effect that change in speed had on physiologic parameters.
In this study, we explored whether umbilical mesenchymal stem cell (UMSC) derived exosomes could prevent aging-induced cardiac dysfunction and determined whether the potential mechanism was mediated by the exosome/lncRNA MALAT1/NF-κB/TNF-α pathway. We discovered that human umbilical cord mesenchymal stem cell- (UMSC-) derived exosomes prevent aging-induced cardiac dysfunction. Silencer RNA against lncRNA MALAT1 blocked the beneficial effects of exosomes. In summary, we discovered that UMSC-derived exosomes prevent aging-induced cardiac dysfunction by releasing novel lncRNA MALAT1, which in turn inhibits ...