Higher plasma levels of F2-isoprostanes are associated with slower psychomotor speed in healthy older adults.

Higher plasma levels of F2-isoprostanes are associated with slower psychomotor speed in healthy older adults. Free Radic Res. 2019 May 22;:1-10 Authors: Camfield DA, Nolidin K, Savage K, Timmer J, Croft K, Tangestani Fard M, Simpson T, Downey L, Scholey A, Pipingas A, Deleuil S, Stough C Abstract Oxidative stress has been identified as a process which is detrimental to brain health, and associated with age-related cognitive declines. Few studies to-date have examined the relationship between in vivo oxidative stress biomarkers and cognitive performance within healthy elderly populations. The current study investigated the relationship between reaction time and oxidative stress, as measured by blood plasma concentrations of F2-isoprostanes using a sample of 251 healthy, non-demented, elderly volunteers (Male; 111: Female 140) aged 60-75 years from the Australian Research Council Longevity Intervention (ARCLI) study cohort. A Jensen Box was used in conjunction with the Hick paradigm in order to differentiate simple from choice reaction time (two, four and eight-choice conditions) as well as movement (MT) and decision times (DT). MT, but not DT, was found to be significantly slower for participants in the high F2-isoprostane group compared to the low F2-isoprostane group, across all stimulus choices. F2-isoprostanes, age and Wechsler Abbreviated Scale of Intelligence (WASI) full scale intelligence quotient (IQ) were found to be signific...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research