Influence of pulse characteristics and power density on stratum corneum permeabilization by dielectric barrier discharge

ConclusionsThe comparison of different DBDs provided insight into the mechanism of DBD-induced SC permeabilization. It also illustrated the need to tailor electrical characteristics of a DBD to optimize it for a particular treatment modality. For future applications in drug delivery it would be beneficial to monitor the permeabilization during a plasma treatment.General significanceOur results provide mechanistic insight into the potential of an emerging interdisciplinary technology – plasma medicine – as a prospective tool or treatment option. While it might become a safe and pain-free method to enhance skin permeation of drug substances, this is also a mechanism to keep in mind when tailoring plasma sources for other uses.

Source: Biochimica et Biophysica Acta (BBA) General Subjects - May 25, 2019 Category: Biochemistry Source Type: research