Influenza Season Winds Down, but Not Done Yet, CDC Says Influenza Season Winds Down, but Not Done Yet, CDC Says

This influenza season is in its final stages but influenza is not completely gone just yet, according to the CDC.Medscape Medical News
Source: Medscape Pathology Headlines - Category: Pathology Tags: Infectious Diseases News Source Type: news

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Routine surveillance and surveillance in response to influenza virus outbreaks in avian species in Vietnam in 2009–2013 resulted in the isolation of numerous H5N1 influenza viruses of clades 1.1.2, 2.3.2.1a, 2.3.2.1b, 2.3.2.1c, and 2.3.4.1. Consistent with other studies, we found that viruses of clade 2.3.2.1c were dominant in Vietnam in 2013 and circulated in the northern, central, and southern parts of the country. Phylogenetic analysis revealed reassortment among viruses of clades 2.3.2.1a, 2.3.2.1b, and 2.3.2.1c; in contrast, no reassortment was detected between clade 2.3.2.1 viruses and viruses of clades 1.1.2 o...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
The quick Sepsis-Related Organ Failure Assessment (qSOFA) score was designed to predict mortality among sepsis patients. However, it has never been used to identify prolonged length of hospital stay (pLOS) in geriatric patients with influenza infection. We conducted this study to clarify this issue.
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
Publication date: Available online 22 June 2019Source: Antiviral ResearchAuthor(s): Jennifer L. McKimm-Breschkin, Susan Barrett, Charley McKenzie-Kludas, Julie McAuley, Victor A. Streltsov, Stephen G. WithersAbstractAn influenza A(H1N1)pdm09 and an influenza B virus were passaged in 3-fluoro(eq)-4-guanidino difluoro sialic acid (3Feq4Gu DFSA), an inhibitor of the influenza neuraminidase (NA) to determine whether resistant variants could be selected. 3Feq4Gu DFSA is a mechanism-based inhibitor, forming a covalent link to Y406 in the NA active site. Given its similarity to the natural substrate, sialic acid, we predicted res...
Source: Antiviral Therapy - Category: Virology Source Type: research
This study is nested within a randomised controlled trial investigating LAIV–microbiome interactions (NCT02972957).FindingsBetween Feb 8, 2017, and April 12, 2017, 118 children were enrolled and received one dose of the Cal09 LAIV from 2016–17. Between Jan 15, 2018, and March 28, 2018, a separate cohort of 135 children were enrolled and received one dose of the NY15 LAIV from 2017–18, of whom 126 children completed the study. Cal09 showed impaired pH1N1 nasopharyngeal shedding (16 of 118 children [14%, 95% CI 8·0–21·1] with shedding at day 2 after administration of LAIV) compared with ...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Publication date: Available online 21 June 2019Source: The Lancet Respiratory MedicineAuthor(s): Cheryl Cohen, Sheena G Sullivan
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Shock figures show 93,000 have already caught influenza this year in the nation - seven times more than the entirety of 2018, according to figures from the Australian government.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Lower respiratory infection caused by human pathogens such as influenza and respiratory syncytial virus (RSV) is a significant healthcare burden that must be addressed. The preferred options to achieve this goal are usually to develop vaccines for prophylaxis, and to develop antiviral small-molecules to treat infected patients with convenient, orally administrable drugs. However, developing a vaccine against RSV poses special challenges with the diminished immune system of infants and the elderly, and finding a universal flu vaccine is difficult because the product must target a large array of viral strains. On the other h...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Excessive inflammation associated with the uncontrolled release of proinflammatory cytokines is the main cause of death from influenza virus infection. Previous studies have indicated that inhibition of interferon gamma-induced protein 10 (IP-10), interleukin-8 (IL-8), monocyte chemoattractant protein 1 (MCP-1), or their cognate receptors has beneficial effects. Here, by using monocytic U937 cells that capable of secreting the three important cytokines during influenza A virus infection, we measured the inhibitory activities on the production of three cytokines of six anti-inflammatory compounds reported in other models of...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Influenza A virus (IAV) is one of the segmented negative-stranded RNA virus, which brings a potentially serious threat to public health and animal husbandry. Mast cells, a kind of immune cells, play an important role in both inherent and adaptive immune response. Previous studies indicated that mast cells support the productive replication of H1N1, H5N1 and H7N2. To date, the distinct of molecular mechanism behind the pathogenesis in mast cells among three different viruses was poorly understood. In the present study, we investigated the more profound genomic profiles for the first time and describe the dynamic change of g...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Abstract Influenza activity* in the United States during the 2018-19 season (September 30, 2018-May 18, 2019) was of moderate severity (1). Nationally, influenza-like illness (ILI)† activity began increasing in November, peaked during mid-February, and returned to below baseline in mid-April; the season lasted 21 weeks,§ making it the longest season in 10 years. Illness attributed to influenza A viruses predominated, with very little influenza B activity. Two waves of influenza A were notable during this extended season: influenza A(H1N1)pdm09 viruses from October 2018 to mid-February 2019 and influenz...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
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