Anatomy, immunohistochemistry, and numerical distribution of human splenic microvessels.

Anatomy, immunohistochemistry, and numerical distribution of human splenic microvessels. Ann Anat. 2019 May 20;: Authors: Almenar S, Rios-Navarro C, Ortega M, Molina P, Ferrandez-Izquierdo A, Ruiz-Sauri A Abstract The microvascular architecture of the spleen plays an important role in the immunological function of this organ. The different types of vessels are related to different reticular cells each with their own immunomodulatory functions. The present study describes an immunohistochemical and morphometric analysis of the various types of vessels in 21 human autopsy non-pathological splenic samples. On an area of 785,656.37 μm2 for each sample, we classified and quantified the type and number of vascular structures, each according to their morphology and immunohistochemical profile, and obtained the ratios between them. The distribution of trabecular vessels and the characteristics of the venules are reviewed. In our material the so-called "cavernous perimarginal sinus" (anatomical structure previously described by Schmidt et al., 1988) was observed and interpreted as a curvilinear venule shaped by the follicle in contact with the trabecular vein. Our material comprised 261 trabeculae (containing 269 arterial sections and 508 venous sections), 30,621 CD34+ capillaries, 7739 CD271+ sheathed capillaries, 2588 CD169+ sheathed capillaries, and 31,124 CD8+ sinusoids. The total area (TA) (14,765,714.88 μm2) occupied by the sinuso...
Source: Annals of Anatomy - Category: Anatomy Authors: Tags: Ann Anat Source Type: research