Correlation between type 2 diabetes, dry eye and Meibomian glands dysfunction

ConclusionsMGD in type 2 diabetic patients is more severe compared with nondiabetic patients. Longer duration of diabetes is associated with major symptoms and changes in MG. Diabetic group showed major changes in lids and tear function, accounting for evaporative dry eye and presenting a high degree of correlation with MG inflammation and obstruction.ResumenObjetivoEvaluar las glándulas de Meibomio, la superficie ocular y la función de la lágrima en pacientes con diabetes tipo 2, y estudiar la correlación entre estas situaciones.MétodosEstudio prospectivo de 76 varones, 37 de ellos con diabetes tipo 2, con una media de duración de entre 7 ± 5 años, y 36 mujeres como grupo control. Tras completar el cuestionario del índice de enfermedad de la superficie ocular (OSDI), se obtuvieron el tiempo de ruptura lagrimal no invasivo (NIBUT) y el patrón de la capa lipídica de la lágrima utilizando interferometría y altura del menisco lagrimal/AML. Se estudió la superficie ocular con tinción verde de lisamina y la morfología de las glándulas con evaluación de la línea de Marx (anomalías del margen del párpado); se expresó la secreción de las glándulas de Meibomio, así como su calidad. Los resultados se analizaron utilizando la pruebas estadísticas Kruskal-Wallis y Mann-Witney, y las correlaciones co...
Source: Journal of Optometry - Category: Opthalmology Source Type: research

Related Links:

Obesity during pregnancy is associated with a 3.5-times increased future risk of type 2 diabetes in the child, according to UK researchers.
Source: Nursing Times - Category: Nursing Source Type: news
Publication date: Available online 18 June 2019Source: Personalized Medicine UniverseAuthor(s): Minako Abe, Hiroyuki AbeAbstractLifestyle-related chronic illnesses, such as metabolic syndrome, type 2 diabetes, cancer, and dementia are rising at an alarming, epidemic rate. In this modern world of increasing lifespan, we are actually decreasing our health span, placing an undue burden on healthcare costs to society. Modern medicine has largely gotten away from addressing key issues to prevent or even reverse some of these chronic conditions. Yet the evidence for successful interventions in four key areas – nutrition, s...
Source: Personalized Medicine Universe - Category: Drugs & Pharmacology Source Type: research
It's suspected by researchers led by Edinburgh University, who analysed the data of 120,000 women, that high blood sugar levels 'programme' adverse health outcomes.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
AbstractObjective and designType 2 diabetes is a pandemic disease characterized by hyperglycemia, ineffective insulin use, and insulin resistance and affecting 1 in 11 people worldwide. Inflammation-related insulin resistance is thought to play an important role in the etiology of the disease. TLR4 is the central receptor of the natural immune system and has an important role as a trigger of the inflammatory response. The IRAK1 and TIRAP are members of the TLR4 pathway and involved in the TLR4-mediated inflammatory response. Genetic variants in the TLR4 gene or in the IRAK1 and TIRAP genes may have an important role in the...
Source: Inflammation Research - Category: Research Source Type: research
AbstractIntroductionSystematic patient education has been reported to improve adherence to treatment, leading to better clinical outcomes. This cluster randomized real-world study investigated the effect of a systematic education program and telephone support on self-reported adherence to oral glucose-lowering treatment in patients with type 2 diabetes mellitus (T2DM).MethodsCenters were randomized (1:1) to provide either standard-of-care (control group) or standard-of-care along with the education program and telephone support (empowerment group). Adherence to treatment and satisfaction with treatment were assessed using ...
Source: Diabetes Therapy - Category: Endocrinology Source Type: research
This study was aimed to evaluate the antidiabetic, dermatoprotective, neuroprotective and antioxidant activities of n-butanol extracts from leaves and flowers of Chrysanthemum fontanesii. β-carotene-linoleic acid, Galvinoxyl radical (GOR), ABTS, hydroxyl radical, reducing power, CUPRAC, O-phenanthroline and metal chelating assays were used to evaluate antioxidant capacity of the extracts. The extracts showed good antioxidant activity and were a good source of phenolics and flavonoids. The enzyme inhibitory activity of the extracts was investigated against key enzymes involved in neurodegenerative [acetylcholinesterase...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Halle Berry, 52, is known to be one of the most beautiful woman in the world, with an enviable body and an impressive career. However, many are unaware of the star ’s battle with type 2 diabetes and how she had to take insulin everyday.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
The sodium-dependent glucose cotransporters (SGLT) are a family of transporters on the luminal side of proximal tubular epithelial cells. SGLT2 normally reabsorbs approximately 90% of the filtered glucose load. SGLT2 is more abundantly expressed in proximal tubular epithelial cells in patients with type 2 diabetes mellitus (DM) than in healthy individuals, leading to excessive glucose reabsorption. SGLT2 inhibitors lower blood glucose by increasing urinary glucose excretion. The glucose-lowering effect is independent of insulin ( β-cell function and insulin sensitivity) and rarely causes hypoglycemia.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Digest Source Type: research
In conclusion, OXTZD could be developed as a therapeutic agent for diabetes and/or serve as a lead compound for further drug design studies targeting PPAR-γ for effective management of type 2 diabetes without inducing weight gain. PMID: 31204468 [PubMed - in process]
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
ConclusionDysfunctional eating is present across the whole spectrum of T2DM and significantly impacts on adherence to dietary restriction and food choices.
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
More News: Diabetes | Diabetes Type 2 | Endocrinology | Men | Opthalmology | Statistics | Study