GSE131617 Genes associated with the progression of neurofibrillary tangles in Alzheimer's disease

Contributors : Akinori Miyashita ; Hiroyuki Hatsuta ; Masataka Kikuchi ; Akihiro Nakaya ; Yuko Saito ; Tamao Tsukie ; Norikazu Hara ; Soichi Ogishima ; Nobutaka Kitamura ; Kohei Akazawa ; Akiyoshi Kakita ; Hitoshi Takahashi ; Shigeo Murayama ; Yasuo Ihara ; Takeshi Ikeuchi ; Ryozo KuwanoSeries Type : Expression profiling by arrayOrganism :Transcriptome analysis of post-mortem brain tissue specimens from three brain regions (BRs), entorinal, temporal and frontal cortices, of 71 Japanese brain-donor subjects to identify genes relevant to the expansion of neurofibrillary tangles. In total, 213 brain tissue specimens (= 71 subjects × 3 BRs) were involved in this study. The spreading of neurofibrillary tangles (NFTs), intraneuronal aggregates of highly phosphorylated microtubule-associated protein tau, across the human brain is correlated with the cognitive severity of Alzheimer’s disease (AD). To identify genes relevant to NFT expansion defined by the Braak stage, we conducted exon array analysis with an exploratory sample set consisting of 213 human post-mortem brain tissue specimens from the entorinal, temporal and frontal cortices of 71 brain-donor subjects: Braak NFT stages 0 (N = 13), I–II (N = 20), III–IV (N = 19) and V–VI (N = 19). We identified eight genes, RELN, PTGS2, MYO5C, TRIL, DCHS2, GRB14, NPAS4 and PHYHD1, associated with the Braak stage. The expression levels of three genes, PHYHD1, MYO5C and GRB14, exhibited reproducible association on ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Source Type: research