TLR3 in Chronic Human Itch: A Keratinocyte-Associated Mechanism of Peripheral Itch Sensitization

The “acute” itch-scratch reflex, considered a protective and evolutionarily conserved mechanism can become dysfunctional in the setting of many chronic skin diseases, resulting in chronic itch (Mollanazar et al. 2016; Talwalkar et al. 2003; Steinhoff et al. 2018). The resultant debilitating itch-scr atch cycle can occur in inflammatory skin diseases, neurological diseases (Meng et al. 2018; Steinhoff et al. 2012) and systemic conditions such as cancer, diabetes, renal or hepatic disorders (Matterne et al.

Source: Journal of Investigative Dermatology - May 23, 2019 Category: Dermatology Authors: Attila G ábor Szöllősi, Ian McDonald, Imre Lőrinc Szabó, Jianghui Meng, Ellen van den Bogaard, Martin Steinhoff Tags: Letters to the Editor Source Type: research