The differentiation-associated keratinocyte protein cornifelin contributes to cell-cell adhesion of epidermal and mucosal keratinocytes

Cornifelin (CNFN) has been identified as protein component of epidermal corneocytes. Here, we investigated the tissue distribution of CNFN and potential consequences of CNFN-deficiency on epithelial function in in vitro models of human skin and oral mucosa.Our detailed bioinformatics and immunostaining analysis revealed that CNFN is not only expressed in human epidermis but also in non-cornifying oral mucosa. In normal epidermis CNFN was confined to the upper granular layer and the stratum corneum.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
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