Geranylgeranyl diphosphate synthase deficiency aggravates lung fibrosis in mice by modulating TGF- β1/BMP-4 signaling.
In conclusion, our findings suggest that GGPPS provides protection against pulmonary fibrosis and the restoration of protein geranylgeranylation may benefit statin-induced lung injury.
PMID: 31120854 [PubMed - as supplied by publisher]
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research