Development of an abbreviated protocol for the polarization and characterization of therapeutic inflammation-resolving monocytes/macrophages

Publication date: May 2019Source: Cytotherapy, Volume 21, Issue 5, SupplementAuthor(s): M. Chan, A. Gomez-Aristizabal, R. Rabani, R. Gandhi, W. Marshall, N. Mahomed, S. ViswanathanBackground &AimMonocytes/macrophages (MΦs) are innate immune cells that exist on a spectrum of pro-inflammatory to inflammation-resolving phenotypes. Their polarization is mediated in vivo through the local microenvironment or ex vivo through exogenous factors. Such ex vivo polarized cells have been used in early clinical trials for a variety of immunosuppressive or reparative indications (e.g. spinal cord injury, liver cirrhosis, transplant rejection). Manufacturing protocols have been variable between studies with similarities in 7-day duration and surface marker characterization.We aim to develop an abbreviated (i.e.
Source: Cytotherapy - Category: Cytology Source Type: research

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