Development of an abbreviated protocol for the polarization and characterization of therapeutic inflammation-resolving monocytes/macrophages
Publication date: May 2019Source: Cytotherapy, Volume 21, Issue 5, SupplementAuthor(s): M. Chan, A. Gomez-Aristizabal, R. Rabani, R. Gandhi, W. Marshall, N. Mahomed, S. ViswanathanBackground &AimMonocytes/macrophages (MΦs) are innate immune cells that exist on a spectrum of pro-inflammatory to inflammation-resolving phenotypes. Their polarization is mediated in vivo through the local microenvironment or ex vivo through exogenous factors. Such ex vivo polarized cells have been used in early clinical trials for a variety of immunosuppressive or reparative indications (e.g. spinal cord injury, liver cirrhosis, transplant rejection). Manufacturing protocols have been variable between studies with similarities in 7-day duration and surface marker characterization.We aim to develop an abbreviated (i.e.
A new technology that allows the heart to be taken from donors after circulatory death may increase the heart donor pool by as much as 30%.Medscape Medical News
Regenerative Medicine, Ahead of Print.
New data suggest a relationship between air pollution and all-cause mortality among heart transplant patients living in ZIP code areas where levels exceed US National Ambient Air Quality Standards limits.Medscape Medical News
Specialists reveal their embarrassing missteps and professional failures in an effort to bolster colleagues and share key takeaways.Medscape Medical News
Neuroplastic changes in somatotopic organization within the motor and somatosensory systems have long been observed. The interruption of afferent and efferent brain-body pathways promotes extensive cortical reorganization. Changes are majorly related to th...
This article aimed to investigate effects of exosomes secreted from miRNA-29b-modified bone marrow mesenchymal stem cells (BMSCs) on SCI. Exosomes were extracted from BMSCs transfected with miRNA-29b or negative control (miR NC). SCI rats were injected intravenously with exosomes (control exosomes, miRNA-29b exosomes) and BMSCs (miR NC, miRNA-29b) through the tail vein. The expression of miRNA-29b in spinal cord tissues of SCI rats was detected by qRT-PCR. The hind limb motor function was evaluated by Basso Beattie Bresnahan (BBB) score. The histopathological damage and neuronal regeneration in spinal cord tissues was obse...
ConclusionsPregnancy after liver transplantation has a favorable outcome with a multidisciplinary team approach. There is a physiological reduction of tacrolimus trough levels during pregnancy for which dose augmentation is not usually required.
Conclusion: Tacrolimus, an immunosuppressant used to prevent rejection in organ transplant, could lead to VS volume shrinkage and hearing improvement. Tacrolimus could be an interesting new therapeutic weapon, especially for VS in Neurofibromatosis type 2.
Conditions: Hepatitis B; Compensated Cirrhosis Interventions: Drug: Entecavir; Drug: Tenofovir Disoproxil Fumarate; Drug: Tenofovir alafenamide Sponsor: Third Affiliated Hospital, Sun Yat-Sen University Recruiting