Evaluation of the effect of Nanoparticles Zinc Oxide/ Camellia sinensis Complex on the kidney of rats treated with Monosodium Glutamate: Antioxidant and Histological Approaches.

Evaluation of the effect of Nanoparticles Zinc Oxide/ Camellia sinensis Complex on the kidney of rats treated with Monosodium Glutamate: Antioxidant and Histological Approaches. Curr Pharm Biotechnol. 2019 May 21;: Authors: El-Shenawy NS, Hamza RZ, Al-Salmi FA, Al-Eisa RA Abstract Zinc oxide nanoparticles (ZnO NPs) are robustly used biomedicine. Moreover, no study had been conducted to explore the consequence of green synthesis of ZnO NPs with Camellia sinensis on kidneys of rats treated with monosodium glutamate (MSG). Therefore, the objective of this research was designed to explore the possible defensive effect of GTE / ZnO NPs against MSG-induced renal stress was investigated at redox and histopathological points. The levels of urea and creatinine increase as the effect of high dose of MSG, in addition, the myeloperoxidase and xanthine oxidase activates elevated significantly with the high dose of MSG. The levels of non-enzymatic antioxidants (uric acid, glutathione, and thiol) were decreased sharply in MSG-treated rats as compared to control group. The data displayed that GTE / ZnO NPs reduced the effects of MSG significantly (p < 0.0001) by reduction of the level peroxidation, and enhancement intracellular antioxidant. These biochemical findings were supported by histopathology examination, which showed minor morphological changes in the kidneys of rats. PMID: 31113341 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Tags: Curr Pharm Biotechnol Source Type: research