Formulation development and accelerated stability testing of a novel sunscreen cream for ultraviolet radiation protection in high altitude areas.

Formulation development and accelerated stability testing of a novel sunscreen cream for ultraviolet radiation protection in high altitude areas. Drug Dev Ind Pharm. 2019 May 22;:1-10 Authors: Sharma Bora N, Mazumder B, Patowary P, Kishor S, Doma Bhutia Y, Chattopadhyay P, Dwivedi SK Abstract The present study is aimed at the development of a sunscreen cream for use in high altitude areas which have been found to possess superior sun protection factor (SPF) along with remarkable antioxidant activity. The topical formulation is a standard oil-in-water emulsion of a combination of United States Food and Drug Administration (US FDA) approved ultraviolet filters; along with melatonin and pumpkin seed oil. The in-silico optimized formulation was characterized using established methods and the stability study was carried out as per International Conference on Harmonization guidelines. The formulation was prepared after requisite pre-formulation analysis by Fourier-transform infrared spectroscopy, differential scanning calorimetric and thermogravimetric analyses; followed by characterization based on color, odor, phase separation, spreadability, specific gravity, homogeneicity, centrifugation and sensitivity. For the stability study, a total of three samples from three batches of the finished product were subjected to the stability study. The samples were analyzed for content uniformity, pH, in vitro SPF, rheology, zeta potential, droplet d...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research