Dermatofibrosarcoma Protuberans: Our 10-year experience on 80 Patients.

Conclusion: Clean margin of excision should be achieved to prevent recurrence of DFSP. Slow Mohs surgery is recommended to treat DFSP. PMID: 31116621 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research

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AbstractPurpose of ReviewThis review presents a selection of regulatory molecules of tumor microenvironmental properties and metastasis. Signaling pathways controlling mesenchymal biology in bone and soft-tissue sarcomas found in children and adolescents are prioritized.Recent FindingsThe tumor microenvironment of pediatric tumors is still relatively unexplored. Highlighted findings are mainly on deregulated genes associated with cell adhesion, migration, and tumor cell dissemination. How these processes are involved in a mesenchymal phenotype and metastasis is further discussed in relation to the epithelial to mesenchymal...
Source: Current Oncology Reports - Category: Cancer & Oncology Source Type: research
Authors: Duran-Moreno J, Kontogeorgakos V, Koumarianou A Abstract Soft tissue sarcomas (STS) are rare tumors; they do not even equate to 1% of all malignant tumor cases. One-fifth of all STS occur in the upper extremities, where epithelioid sarcoma, synovial sarcoma, clear cell sarcoma and malignant fibrohistiocytoma are the most frequent subtypes. Surgical resection is the cornerstone of treatment. However, accomplishment of optimal oncological and functional results of STS of the upper extremities may represent a challenge for hand surgeons, due to the complex anatomy. In several cases, preoperative therapies are...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Condition:   Soft Tissue Sarcoma Interventions:   Drug: Doxil;   Drug: Doxorubicin Sponsor:   Fox Chase Cancer Center Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion.Initial diagnostic management requires improvement, especially outside of specialized centers.Implications for Practice.This article supports the essential need to refer patients with soft tissue tumors to specialized centers to improve the management of sarcomas beginning at the diagnostic phase. Indeed, the reported data were very similar to those already described at the national level of the NetSarc network and indicate the necessity to keep raising awareness about this simple issue: early referral to reference centers will save lives.
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Sarcomas Source Type: research
nni Soft tissue sarcoma (STS) is a rare malignancy of mesenchymal origin classified into more than 50 different subtypes with distinct clinical and pathologic features. Despite the poor prognosis in the majority of patients, only modest improvements in treatment strategies have been achieved, largely due to the rarity and heterogeneity of these tumors. Therefore, the discovery of new prognostic and predictive biomarkers, together with new therapeutic targets, is of enormous interest. Phosphatase and tensin homolog (PTEN) is a well-known tumor suppressor that commonly loses its function via mutation, deletion, transcrip...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Changhua Wu, Liang Wang, Lei Guo, Lihong Zhang, Jing LiJournal of Cancer Research and Therapeutics 2019 15(4):947-952 Undifferentiated sarcoma (UNDS) of the soft tissue is an exceedingly rare disease. Its diagnosis depends mainly on molecular and immunohistochemical analyses to exclude other soft-tissue sarcomas. It is difficult to confirm a positive diagnosis by imaging pathological features because of their rarity and similarity with other conditions. Since 2013, only 13 cases of undifferentiated soft-tissue sarcoma, mostly diagnosed through imaging of solid tumors in infant and children, have been reported. The authors...
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
PALETTE is a phase 3 trial that demonstrated single-agent activity of pazopanib in advanced soft tissue sarcomas (aSTS). We performed retrospective subgroup analyses to explore potential relationships between ...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
ConclusionsThis case series underscores the value of targeted immunotherapy in treating angiosarcoma. It also identifies genetic heterogeneity of cutaneous angiosarcomas and discusses specific genetic findings that may explain reported benefits from immunotherapy.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
CONCLUSION: More in-depth knowledge is required for many sarcomas to link their genetic alterations to tumorigenesis in order to develop efficient personalised treatment strategies. Clinical trial designs need to be adapted to evaluate new therapeutic strategies in these ultra-rare tumours and their various sub-types more efficaciously. PMID: 31396640 [PubMed - as supplied by publisher]
Source: Der Orthopade - Category: Orthopaedics Authors: Tags: Orthopade Source Type: research
Publication date: Available online 1 August 2019Source: Respiratory Medicine Case ReportsAuthor(s): Jose N. Sancho-Chust, Enrique Cases Viedma, Raquel Martinez Tomas, Eusebi Chiner VivesAbstractHemoptysis is a manifestation of a wide variety of diseases. Endobronchial metastases from nonpulmonary neoplasms are unusual. Among these causes, soft-tissue sarcoma is also discretely rare and scarcely documented. Argon plasma coagulation is a useful tool for the interventional pulmonologist that can allow control of bleeding from these lesions. Here we report a case of hemoptysis from an endobronchial metastasis of soft-tissue sa...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
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