Characterization of the non-glandular gastric region microbiota in Helicobacter suis -infected versus non-infected pigs identifies a potential role for Fusobacterium gastrosuis in gastric ulceration

AbstractHelicobacter suis has been associated with development of gastric ulcers in the non-glandular part of the porcine stomach, possibly by affecting gastric acid secretion and altering the gastric microbiota.Fusobacterium gastrosuis is highly abundant in the gastric microbiota ofH. suis-infected pigs and it was hypothesized that this micro-organism could play a role in the development of gastric ulceration. The aim of this study was to obtain further insights in the influence of a naturally acquiredH. suis infection on the microbiota of the non-glandular part of the porcine stomach and in the pathogenic potential ofF. gastrosuis. Infection withH. suis influenced the relative abundance of several taxa at phylum, family, genus and species level.H. suis-infected pigs showed a significantly higher colonization rate ofF. gastrosuis in the non-glandular gastric region compared to non-infected pigs. In vitro, viableF. gastrosuis strains as well as their lysate induced death of both gastric and oesophageal epithelial cell lines. These gastric cell death inducing bacterial components were heat-labile. Genomic analysis revealed that genes are present in theF. gastrosuis genome with sequence similarity to genes described in otherFusobacterium spp. that encode factors involved in adhesion, invasion and induction of cell death as well as in immune evasion. We hypothesize that, in a gastric environment altered byH. suis, colonization and invasion of the non-glandular porcine stomach re...
Source: Veterinary Research - Category: Veterinary Research Source Type: research

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