Sensitivity of Ablation Targets Prediction to Electrophysiological Parameter Variability in Image-Based Computational Models of Ventricular Tachycardia in Post-infarction Patients

Ventricular tachycardia (VT), which could lead to sudden cardiac death, occurs frequently in patients with myocardial infarction. Computational modeling has emerged as a powerful platform for the non-invasive investigation of lethal heart rhythm disorders in post-infarction patients and for guiding patient VT ablation. However, it remains unclear how VT dynamics and predicted ablation targets are influenced by inter-patient variability in action potential duration (APD) and conduction velocity (CV). The goal of this study was to systematically assess the effect of changes in the electrophysiological parameters on the induced VTs and predicted ablation targets in personalized models of post-infarction hearts. Simulations were conducted in 5 patient-specific left ventricular models reconstructed from late gadolinium-enhanced magnetic resonance imaging scans. We comprehensively characterized all possible pre-ablation and post-ablation VTs in simulations conducted with either an "average human VT"-based electrophysiological representation (i.e., EPavg) or with ±10% APD or CV (i.e., EPvar); additional simulations were also executed in some models for an extended range of these paramaters. The results showed that: 1) a subset of reentries (76.2%–100%, depending on EP parameter set) conducted with ±10% APD/CV was observed in approximately the same locations as reentries observed in EPavg cases; 2) emergent VTs could be induced sometimes after ablation in EPavg models, and these ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research