ASAP In Vivo Proteome of Pseudomonas aeruginosa in Airways of Cystic Fibrosis Patients

Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.9b00122
Source: Journal of Proteome Research - Category: Biochemistry Authors: Source Type: research

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Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
Sleep irregularities including reduced sleep efficiency, nocturnal cough, and less REM sleep relative to controls have been observed in pediatric CF [1 –8] and correlation between forced expiratory volume in one second (FEV1) and objective sleep measures indicates a relationship between sleep disturbance and severity of CF lung disease [1,5,7]. Further, impaired sleep in youth with CF is associated with compromised mood, problematic behaviors, an d reduced health related quality of life [9,10]. To date, most studies examining sleep in youth with CF have predominantly enrolled older patients with evidence of lung dysfunction.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Source Type: research
Background: Cystic fibrosis-related liver disease (CFLD) is the leading nonpulmonary cause of mortality in cystic fibrosis (CF). We evaluated and compared the burden of disease and nonrespiratory comorbidities of those with severe CFLD and those without (noCFLD). Methods: A retrospective nationwide (Australia) longitudinal review (from 1998 to 2016) of severe CFLD patients compared with noCFLD controls (matched 1 : 1 for age, genotype, pancreatic insufficiency, and center). Results: One hundred sixty-six patients with severe CFLD and 166 with noCFLD were identified. Forced expiratory volume in 1 second percenta...
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Article: Hepatology Source Type: research
Conclusions: Malnutrition remains a serious public health problem, and thus, the development of novel treatment methods is highly essential. PERT is one of the most commonly considered alternatives, although there is little documentation of PERT in the literature. In the present study, although PERT resulted in higher weight gain, it established no significant difference between the 2 groups.
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Pancreatology Source Type: research
Chronic inflammation is a hallmark among patients with cystic fibrosis (CF). We explored whether mutation-induced (F508del) misfolding of the cystic fibrosis transmembrane conductance regulator (CFTR), and/or secondary colonization with opportunistic pathogens, activate tissue remodeling and innate immune response drivers.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Source Type: research
Condition:   Cystic Fibrosis Intervention:   Sponsor:   National Jewish Health Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Progressive lung disease is still the main cause of death in cystic fibrosis (CF) patients (O'Sullivan and Freedman, 2009). In the CF lung, viscous secretions, impaired mucociliary clearance and insufficient local immune responses result in bacterial and fungal colonization, and subsequent chronic inflammation (TS, 2012).
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Condition:   Cystic Fibrosis Intervention:   Sponsor:   National Jewish Health Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Holsclaw DS, Grand RJ, Shwachman H. Massive hemoptysis in cystic fibrosis. J Pediatr 1970;76:829-38.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Original Article Source Type: research
As it has been long known that the sweat gland is affected in Cystic Fibrosis (CF), the chloride concentration in induced sweat has been the gold standard in CF diagnostics for decades [1].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Source Type: research
More News: Biochemistry | Cystic Fibrosis