Okadaic acid activates Wnt/ β-catenin-signaling in human HepaRG cells.

In conclusion, our results show a significant induction of the canonical Wnt/β-catenin-signaling pathway by OA in human liver cells. Our data contribute to a better understanding of the molecular mechanisms underlying OA-induced carcinogenesis.
PMID: 31115591 [PubMed - as supplied by publisher]

Source: Archives of Toxicology - May 20, 2019 Category: Toxicology Authors: Dietrich J, Sommersdorf C, Gohlke S, Poetz O, Traenkle B, Rothbauer U, Hessel-Pras S, Lampen A, Braeuning A Tags: Arch Toxicol Source Type: research