Efficacy of Endoscopic Submucosal Dissection of Esophageal Neoplasms under General Anesthesia.

This study aims to evaluate the efficacy and safety of esophageal ESD under GA. Methods: A total of 227 lesions from 198 consecutive patients with superficial esophageal neoplasms treated by ESD at 3 Japanese institutions between April 2011 and September 2017 were included in this retrospective study. For ESD, GA and deep sedation (DS) were used in 102 (51.5%, GA group) and 96 patients (48.5%, DS group), respectively. Results: There were no statistically significant differences in age, sex, or comorbidities between the groups. In the GA group, the tumor size was larger (21 [3-77] mm vs. 14 [3-63] mm, p
Source: Clinical Endoscopy - Category: Gastroenterology Tags: Clin Endosc Source Type: research

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Contributors : Ruo-Pan  Huang ; Xinchun ChenSeries Type : Protein profiling by protein arrayOrganism : Homo sapiensMycobacterium tuberculosis (Mtb) antigen-specific cellular response is promising for detectionof Mtb infection, but not efficient for diagnosis of TB. We firstly identified 16 TB disease-specific protein markers measured in the culture supernatant of Mtb-stimulated whole blood using a 640 human proteins array, the highest throughput antibody-based protein array available at the time when we did this study. Potential TB-related proteins were then analyzed across three different patient cohorts comprised of...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Protein profiling by protein array Homo sapiens Source Type: research
ConclusionInfectious diseases are one of the most common factorsto hospitalize diabetic patients (27.7%), most of whom had diabetic foot infections, pneumonia, and soft tissue abscess.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Conclusions A serum Aspergillus-specific IgG test is a valuable tool for the serologic diagnosis of CPA and SAIA, while an Aspergillus-specific IgM test is only modestly specific for the diagnosis of SAIA. Overall, the Aspergillus-specific IgG test is more valuable compared to IgM for the treatment duration monitoring.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
AbstractPathological examination of a suckling male lamb showed severe viral pneumonia with suspected bacterial superinfection. Adenovirus was detected by immunohistochemical examination of the affected lung samples. Detection of the suspected adenovirus by PCR and subsequent isolation of the virus were successful. Using next-generation sequencing, the full genome of this ovine adenovirus was sequenced and analysed. A genome sequence comparison showed that it was a novel mastadenovirus type (named “ovine adenovirus 8”) that did not belong to any of the established adenovirus species. The genome is 36,206 bp lon...
Source: Archives of Virology - Category: Virology Source Type: research
In this study, two novel phages (ISF3 and ISF6) of a methylotrophicRaoultella strain were isolated from sewage. To characterize the isolated phages, morphological features, protein profiles, restriction digestion patterns, and partial genome sequences were studied. Despite morphological differences, electron microscopy revealed that both phages had an icosahedral capsid connected to a contractile tail, suggesting that ISF3 and ISF6 both belong to the familyMyoviridae. Partial nucleotide sequences of the ISF3 genome showed 99% to 100% identity to DNA ofKlebsiella pneumonia phages KP15, KP27 and BMBT1; however, the restricti...
Source: Archives of Virology - Category: Virology Source Type: research
Publication date: Available online 24 June 2019Source: Respiratory InvestigationAuthor(s): Tomoo Kishaba
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
Conditions:   Pneumonia;   Mechanical Ventilation Complication Intervention:   Diagnostic Test: taqman array card Sponsors:   Cambridge University Hospitals NHS Foundation Trust;   University of Cambridge;   Public Health England Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Discussion Transplantation is not a common problem for primary care physicians but when a child’s disease has progressed to end-stage organ failure, transplantation can be the only treatment available. While the primary care provider usually is not involved in the daily management of patients before, during and after transplantation, they can be involved in many areas. These can include providing appropriate primary and acute care, ordering and obtaining necessary medical tests, medications and equipment, assisting with medical insurance, providing medical history and records to consultants, translating medical infor...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
In the geriatric age group, few studies demonstrate the efficacy of aggressive treatment. Often, a more palliative approach is wanted; such an approach can lead to better quality of life and even a longer life. The author discusses the limits of medical interventions in the elderly, the paucity of data, and the benefits of palliation in certain medical conditions, including dementia, Parkinson, depression, arthritis, congestive heart failure, and pneumonia. The role of frailty is addressed; specific goals of palliative care are delineated, such as reduction of polypharmacy, fall prevention, pain reduction, and the central ...
Source: Primary Care: Clinics in Office Practice - Category: Primary Care Authors: Source Type: research
ConclusionsThe possibility of tuberculosis should be considered in the differential diagnosis of patients with pneumonia, persistent fever, and those with focal signs or symptoms suggestive of tuberculosis. Despite having a sensitive organism, the infection was difficult to treat, even with the addition of two second-line drugs. The standard anti-tuberculosis therapy is usually adequate, but response may be slow, and inadequate even if the organism is sensitive requiring the addition of second-line agents.
Source: Infection - Category: Infectious Diseases Source Type: research
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