Avoiding Neuromuscular Blockers to Reduce Complications

Conditions:   Respiratory Failure;   Respiratory Infection;   Aspiration Pneumonia;   Pneumonitis;   Atelectasis;   Bronchospasm Interventions:   Drug: Neuromuscular Blocking Agents;   Drug: Anesthetic Adjuncts Sponsor:   Beth Israel Deaconess Medical Center Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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We previously corroborated benefits of the Trendelenburg position in the prevention of ventilator-associated pneumonia (VAP). We now investigate its potential effects on the brain versus the semirecumbent position. We studied 17 anesthetized pigs and randomized to be ventilated and positioned as follows: duty cycle (TI/TTOT) of 0.33, without positive end-expiratory pressure (PEEP), placed with the bed oriented 30° in anti-Trendelenburg (control group); positioned as in the control group, with TI/TTOT adjusted to achieve an expiratory flow bias, PEEP of 5 cm H2O (IRV-PEEP); positioned in 5° TP and ventilated as in...
Source: Shock - Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research
Abstract BACKGROUND: Pulmonary complications after total joint arthroplasty (TJA) are uncommon but have significant cost impact. Total hip arthroplasty (THA) and total knee arthroplasty (TKA) are 2 of the 5 top procedures requiring inpatient stay within the United States. Subsequent pulmonary complications therefore may impose substantial cost burden for US health care. The purpose of this study was to describe the incidence, risk factors, and clinical implications of pulmonary complications (ie, pneumonia, respiratory failure, pulmonary embolism [PE], and aspiration) after TJA in the United States. METHODS: ...
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
AimThe mortality rate of the postoperative pneumonia group is significantly higher than that of non ‐pneumonia group. Five of 38 risk factors were found to be significantly related to postoperative pneumonia (P
Source: Surgical Practice - Category: Surgery Authors: Tags: Original Article Source Type: research
Conditions:   Respiratory Failure;   Respiratory Infection;   Aspiration Pneumonia;   Pneumonitis;   Atelectasis;   Bronchospasm Interventions:   Drug: Neuromuscular Blocking Agents;   Drug: Anesthetic Adjuncts Sponsor:   Beth Israel Deaconess Medical Center Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study aims to evaluate the efficacy and safety of esophageal ESD under GA. Methods: A total of 227 lesions from 198 consecutive patients with superficial esophageal neoplasms treated by ESD at 3 Japanese institutions between April 2011 and September 2017 were included in this retrospective study. For ESD, GA and deep sedation (DS) were used in 102 (51.5%, GA group) and 96 patients (48.5%, DS group), respectively. Results: There were no statistically significant differences in age, sex, or comorbidities between the groups. In the GA group, the tumor size was larger (21 [3-77] mm vs. 14 [3-63] mm, p
Source: Clinical Endoscopy - Category: Gastroenterology Tags: Clin Endosc Source Type: research
On April 30, 2019, Capsule Tech announced that it is acquiring Bernoulli Health for an undisclosed amount. This acquisition combines two market leaders in the medical IoT, IoMT, biomedical medical device integration (BMDI), medical device data system (MDDS), medical device connectivity, or whatever you call this market. Medical devices are by far the greatest source of data in health care. For many years the vast majority of medical device data simply scrolled off the screen, never reaching clinicians for analysis and alerting. Capturing this data and using it to better diagnose, treat and monitor patients is finally t...
Source: Medical Connectivity Consulting - Category: Information Technology Authors: Tags: Clinical Alarms Clinical Decision Support Company Profiles Connectivity Remote Monitoring Strategy & Planning Surveillance Monitoring Source Type: blogs
Rationale: Perioperative management of patients with bronchobiliary fistula (BBF) is an anesthetic challenge because they typically exhibit poor lung function preoperatively, require meticulous lung isolation intraoperatively and need postoperative respiratory support. Patient concerns: A 44-year-old man with a past surgical history of pancreaticoduodenectomy presented fluctuating fever, jaundice, dyspnea and yellowish sputum. Despite intravenous antibiotic treatment and repeated percutaneous drainage, patient showed gradual deterioration with hypoxemia, and uncontrolled pneumonia. Diagnoses: The patient was diagno...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
A charmed (?) source for pharmaceuticals, ex-magician John A. Hamlin added the botanicals sassafras and cloves to a chloroform elixir that also contained turpentine, ammonia, and camphor. He then bottled it in Chicago (bottom left) as “Hamlins Wizard Oil.” This magical medicine was peddled as an external liniment and topical remedy for toothache and earache. Unfortunately, Hamlin also began encouraging internal use of his panacea as a cure for headache, diphtheria, pneumonia, rabies, and cancer. (Granted, the roughly 60% alco hol content may have provided imbibers with transient relief from their aches and pain...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
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