Research on Optimal Immunization Strategy of Hepatitis B Vaccine in Chronic Kidney Disease Population

Condition:   Hepatitis B Vaccine Interventions:   Biological: 20 µg recombinant hepatitis B vaccine at months 0, 1, and 6;   Biological: 20 µg recombinant hepatitis B vaccine at months 0, 1, 2,and 6;   Biological: 60 µg recombinant hepatitis B vaccine at months 0, 1, 2,and 6 Sponsors:   Shanxi Medical University;   Centers for Disease Control and Prevention, China Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Publication date: May 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 3Author(s): Vivek Soi, Sandeep SomanPatients with end-stage renal disease are at risk for contracting hepatitis B virus (HBV) because of their exposure to blood products and compromised immune status. Despite a decrease in the incidence of HBV infection, continued vigilance in the form of surveillance is imperative in preventing the spread of this robust DNA virus. Regular review of serologic markers with isolation and decontamination practices as appropriate are paramount to maintaining a safe environment for dialysis to occur. Vaccinat...
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research
Condition:   Hepatitis B Vaccine Interventions:   Biological: 20 µg recombinant hepatitis B vaccine at months 0, 1, and 6;   Biological: 20 µg recombinant hepatitis B vaccine at months 0, 1, 2,and 6;   Biological: 60 µg recombinant hepatitis B vaccine at months 0, 1, 2,and 6 Sponsors:   Shanxi Medical University;   Centers for Disease Control and Prevention, China Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSION: The Bayesian network confirmed that both kidney function and nutritional status of patients are important factors to explain the success of vaccination against hepatitis B in CKD patients before dialysis. For research purposes, before an external validation, the network can be used online at www.hed.cc/?s=Bhepatitis&n=ReseauhepatiteBsup10.neta. PMID: 31129001 [PubMed - as supplied by publisher]
Source: Nephrologie and Therapeutique - Category: Urology & Nephrology Authors: Tags: Nephrol Ther Source Type: research
Publication date: January 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 1Author(s): Vivek Soi, Chantale Daifi, Jerry Yee, Elizabeth AdamsAn in-depth understanding of viral hepatitis is important to the care of patients with end-stage renal disease undergoing hemodialysis. Both hepatitis B and C viruses are acquired through hematogenous spread and can lead to horizontal transmission. Concurrent hepatic and renal injuries have ominous outcomes with significant morbidity. Hepatitis B incidence has decreased through practices including vaccination of nonimmune individuals and isolation of patients with the d...
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research
This study aimed to assess the seroconversion and persistence of protective immunity following hepatitis B vaccination in children with CKD. This prospective observational study was conducted in a tertiary pediatric nephrology centre to assess the seroconversion and maintenance of antibody titers (>10 mIU/mL) at one year following hepatitis B vaccination (10 μg at 0, 1, and 2 months) in children with CKD Stages II to V. Those who did not seroconvert after the schedule were re-vaccinated, and antibody titers were checked. Categorical data were expressed as proportions and analyzed using the Chi-square test. Pearson's ...
Source: Saudi Journal of Kidney Diseases and Transplantation - Category: Urology & Nephrology Authors: Tags: Saudi J Kidney Dis Transpl Source Type: research
AbstractPurpose of the ReviewThis review addresses clinical challenges of hepatitis B virus (HBV) infection in patients with chronic kidney disease and renal transplant recipients.Recent FindingsProphylactic antiviral therapy with nucleos(t)ide analogues is key to prevent HBV reactivation in renal transplant recipients. In addition, attaining adequate immunity following vaccination against HBV may permit transplantation of renal grafts from donors with evidence of prior HBV infection. The role of nucleos(t)ide analogues for treatment of recurrent or de novo HBV infection in renal transplant recipients is well established a...
Source: Current Hepatitis Reports - Category: Infectious Diseases Source Type: research
Conclusion: Seroconversion rates of the two groups were not significantly different after completion of HBV vaccination, but only patients in the group receiving the double dose were able to maintain seroconversion 6 months later. The proper hepatitis B vaccination for patients with CKD stage 3 with negative makers of HBV should be immunization with a four-dose regimen using 40 μg of vaccine. PMID: 29926711 [PubMed - in process]
Source: Journal of the Medical Association of Thailand = Chotmaihet thangphaet - Category: General Medicine Tags: J Med Assoc Thai Source Type: research
Conclusion: There are variations in vaccination practice across Europe. Children with CKD, those undergoing dialysis, and transplant candidates should receive age-appropriate vaccinations before RTx as well as before the transition to adult nephrology clinics and antibody levels should be monitored to evaluate the immunization status before and after RTx.Nephron
Source: Nephron - Category: Urology & Nephrology Source Type: research
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