Risk Factors for Infection After Intramedullary Nailing of Open Tibial Shaft Fractures in Low- and Middle-Income Countries

Objectives: (1) To determine the infection rate after fixation of open tibial shaft fractures using the Surgical Implant Generation Network (SIGN) intramedullary nail in low- and middle-income countries (LMICs) and (2) to identify risk factors for infection. Design: Prospective cohort study using an international online database. Setting: Multiple hospitals in LMICs worldwide. Patients/Participants: A total of 1061 open tibia fractures treated with the SIGN nail in LMICs between March 2000 and February 2013. Intervention: Intravenous antibiotic administration, surgical debridement, and definitive intramedullary nailing within 14 days of injury. Main Outcome Measurements: Deep or superficial infection at follow-up, implant breakage/loosening, angular deformity>10 degrees, repeat surgery, radiographic union, weight bearing, and ability to kneel. Results: The overall infection rate was 11.9%. Infection rates by the Gustilo and Anderson classification were type 1: 5.1%, type II: 12.6%, type IIIa: 12.5%, type IIIb: 29.1%, and type IIIc: 16.7% (P = 0.001 between groups). Patients who developed infection had a longer mean time from injury to definitive surgery (4.7 vs. 3.9 days, P = 0.03) and from injury to wound closure (13.7 vs. 3.6 days, P
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Original Article Source Type: research