Concurrent positive anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody with reducing body myopathy: possible double trouble

Immune mediated necrotizing myopathy (IMNM), a recently recognized but a common entity among the heterogenous group of inflammatory myopathies, has been classified by the ENMC Immune-Mediated Necrotizing Myopathies Working Group into 1) anti-signal recognition particle (anti-SRP) positive IMNM or anti-SRP myopathy, 2) anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) positive IMNM or anti-HMGCR myopathy, and 3) antibody negative IMNM using integrated clinical, serological, and pathological criteria [1].

Source: Neuromuscular Disorders - May 22, 2019 Category: Neurology Authors: Jantima Tanboon, Oranee Sanmaneechai, Sirirat Charuvanij, Tumtip Sangruchi, Angeles S. Galindo-Feria, Ingrid E. Lundberg, Yuko Ohnuki, Takashi Shiina, Shigeaki Suzuki, Ichizo Nishino Tags: Case report Source Type: research