The role of perioperative systemic therapy in localized pancreatic neuroendocrine neoplasms

Background The role of perioperative systemic therapy (PST) in the management of localized pancreatic neuroendocrine neoplasms (PanNEN) is unclear. Objectives We aimed to evaluate the benefit of PST compared to surgical alone (SA) in patients with localized PanNEN. Method We selected patients with stage I-III PanNEN who underwent curative-intent surgical resection in National Cancer Database from 2006 to 2014. Patients who had both PST and surgical resection were matched with patients who received SA by propensity score at 1-to-1 ratio with nearest neighbor method. Results 4,892 patients were included in this study with median age of 60 years. Factors associated with significant more use of PST compared to SA included age
Source: Neuroendocrinology - Category: Endocrinology Source Type: research