Evaluation of pathogen P21 protein as a potential modulator of the protective immunity induced by Trypanosoma cruzi attenuated parasites.

CONCLUSION: Our results demonstrated that rP21 may have adjuvant capacity able to modify the cytokine immune profile elicited by attenuated parasites. PMID: 31116244 [PubMed - in process]
Source: Memorias do Instituto Oswaldo Cruz - Category: Infectious Diseases Authors: Tags: Mem Inst Oswaldo Cruz Source Type: research

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An effective vaccine against the Plasmodium parasite is likely to require the induction of robust antibody and T cell responses. Chimeric virus-like particles are an effective vaccine platform for induction of antibody responses, but their capacity to induce robust cellular responses and protection against pathogen challenge when incorporating T cell epitopes has not been established. To evaluate this, we produced chimeric constructs using the murine polyomavirus structural protein with surface-exposed CD8+ or CD4+ T cell or B cell repeat epitopes derived from the Plasmodium yoelii circumsporozoite protein, and assessed im...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
AbstractPost mortem examinations were performed on the carcasses of two male White Fulani calves that reportedly died within a herd of about 45 cattle. Similar deaths were recorded in three other calves of the same age bracket (8 –13 weeks) within a 5-day period about two weeks ago but no post mortem examinations were conducted on any of them unlike this present case. Contagious bovine pleuropneumonitis vaccination was reportedly up-to-date and the herd were recently treated with Diminazene aceturate (Berenil®) and Oxytetracycline® LA about two (2) months ago against haemoparasitism. Carcasses were in po...
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research
Tackling relapsingPlasmodium vivax and zoonoticPlasmodium knowlesi infections is critical to reducing malaria incidence and mortality worldwide. Understanding the biology of these important and related parasites was previously constrained by the lack of robust molecular and genetic approaches. Here, we establish CRISPR-Cas9 genome editing in a culture-adaptedP. knowlesi strain and define parameters for optimal homology-driven repair. We establish a scalable protocol for the production of repair templates by PCR and demonstrate the flexibility of the system by tagging proteins with distinct cellular localisations. Using ite...
Source: eLife - Category: Biomedical Science Tags: Genetics and Genomics Microbiology and Infectious Disease Source Type: research
Publication date: Available online 15 June 2019Source: Microbial PathogenesisAuthor(s): Abdol Sattar Pagheh, Shahabeddin Sarvi, Shirzad Gholami, Hossein Asgarian-Omran, Reza Valadan, Hadi Hassannia, Ehsan Ahmadpour, Mahdi Fasihi-Ramandie, Samira Dodangeh, Zahra Hosseni-khah, Ahmad DaryaniAbstractToxoplasma gondii, the etiological agent of toxoplasmosis, can cause severe or lethal damages in both animals and man. So, tends to develop a more effective vaccine to prevent this disease is extremely needed and would be so prominent. The novel dense granule antigen 14 (GRA14) has been identified as a potential vaccine candidate a...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
ConclusionsIn this review, we summarize antagonistic concurrent infections involving parasites and provide a functional framework for in-depth studies of the underlying mechanisms of coinfection with different microorganisms, which will hasten the development of promising antimicrobial alternatives, such as novel antibacterial vaccines or biological methods of controlling infectious diseases, thus relieving the overwhelming burden of ever-increasing antimicrobial resistance.
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
Conclusions: The ability to label and image non-GMO Plasmodium sporozoites provides the basis for detailed studies on the human skin stage of malaria with potential for in vivo translation. As such, it is an important tool for development of vaccines based on attenuated sporozoites and their route of administration.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
(University of Oxford) Researchers from the University of Oxford, along with partners from five institutions around the world, have identified the human antibodies that prevent the malaria parasite from entering blood cells, which may be key to creating a highly effective malaria vaccination. The results of the study were published today in the journal Cell.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Publication date: Available online 12 June 2019Source: Parasitology InternationalAuthor(s): Vipin Kumar Deo, Yu Inagaki, Elsa Herdiana Murhandarwati, Widya Asmara, Takatsugu Miyazaki, Tatsuya Kato, Enoch Y. ParkAbstractPlasmodium falciparum is a blood protozoan parasite, transmitted by Anopheles mosquitoes vectors, that can cause morbidity and even leads to mortality in tropical countries. Strategies are directed to combat malaria including development of diagnostic tools, serological markers and vaccinations. A target under intensive studies is Merozoite Surface Protein (MSP)-3. The aim of this study is to express and pur...
Source: Parasitology International - Category: Parasitology Source Type: research
Publication date: Available online 11 June 2019Source: Veterinary ParasitologyAuthor(s): María E. Elguero, Mariela L. Tomazic, María G. Montes, Mónica Florin-Christensen, Leonhard Schnittger, Alejandro D. NusblatAbstractCryptosporidium parvum is a protozoan parasite of the phylum Apicomplexa responsible for cryptosporidiosis in calves, a disease that causes significant diarrhea and impairs gain of body weight, generating important production losses. As to now, no effective drugs or vaccines are available for the treatment or prevention of bovine cryptosporidiosis. Several reports suggest that developme...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
Publication date: Available online 11 June 2019Source: Fish &Shellfish ImmunologyAuthor(s): Yeny Leal, Janet Velazquez, Liz Hernandez, Jaya Kumari Swain, Alianet Rodríguez Rodríguez, Rebeca Martínez, Claudia García, Yassel Ramos, Mario Pablo Estrada, Yamila CarpioAbstractThe development of vaccines employing conserved protein antigens, for instance ribosomal protein P0, has as disadvantage the high degree of identity between pathogen and host proteins due to possible induction of tolerance or auto antibodies in the host organism. To overcome this drawback, peptide-based vaccines have been de...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
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