Ovine pulmonary adenocarcinoma: a transmissible lung cancer of sheep, difficult to control

Publication date: Available online 23 May 2019Source: Small Ruminant ResearchAuthor(s): A. Ortín, M. De las Heras, M. Borobia, M.A. Ramo, M. Ortega, M. Ruíz de ArcauteAbstractOvine pulmonary adenocarcinoma (OPA) is a contagious lung cancer of sheep caused by jaagsiekte sheep retrovirus (JSRV), which induces the transformation of secretory epithelial cells of the distal respiratory tract. The disease has been recorded in the major sheep rearing areas with the exceptions of Australia and New Zealand, and is clinically characterized by a chronic respiratory process that often involves the production of pulmonary fluid that is discharged from the nostrils in final stages of the disease while the “wheelbarrow” test is performed. The respiratory route has been accepted to be the most important natural mode of transmission for JSRV but colostrum and milk can transmit JSRV to lambs. In OPA affected flocks, under endemic conditions, JSRV infected sheep may be present in a high proportion but very few of them develop clinical signs. Such apparently healthy animals are responsible for the spread of the disease because is difficult to identify infected animals or preclinical stages. There are not serological diagnostic tests due to the lack of a detectable immune response in JSRV infected animals, and although blood molecular tests are available their sensitivity is low. For this reason the disease has failed to be controlled so far and continues to cause signif...
Source: Small Ruminant Research - Category: Zoology Source Type: research

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In this study, we present the first molecular phylogeny of Pyrgomorphidae that includes the members of all four New World tribes and representative genera from the Old World based on entire mitochondrial genome and four nuclear genes to investigate the biogeography of this fascinating lineage. Our results recover Pyrgomorphidae as monophyletic and the New World Pyrgomorphidae as a paraphyletic group comprising three clades, consisting of: 1) The Caribbean Jaragua + the South American Algete; 2) The Mexican and Central American Sphenarium + Prosphena; and 3) The Mexican lineages Ichthiacridini + Ichthyotettigini. The diverg...
Source: Molecular Phylogenetics and Evolution - Category: Molecular Biology Source Type: research
Publication date: Available online 15 June 2019Source: MethodsAuthor(s): Rui Yan, Fei Ren, Zihao Wang, Lihua Wang, Tong Zhang, Yudong Liu, Xiaosong Rao, Chunhou Zheng, Fa ZhangAbstractEven with the rapid advances in medical sciences, histopathological diagnosis is still considered the gold standard in diagnosing cancer. However, the complexity of histopathological images and the dramatic increase in workload make this task time consuming, and the results may be subject to pathologist subjectivity. Therefore, the development of automatic and precise histopathological image analysis methods is essential for the field. In thi...
Source: Methods - Category: Molecular Biology Source Type: research
Publication date: Available online 15 June 2019Source: Journal of Molecular LiquidsAuthor(s): Prakash Bansode, Pradnya Patil, Prafulla Choudhari, Manish Bhatia, Apurva Birajdar, Indumathi Somasundaram, Gajanan RashinkarAbstractA novel series of ferrocene tethered ionic liquids (ILs) has been synthesized by quaternization of 1-N-(ferrocenylmethyl)benzimidazole, 1-N-(ferrocenylmethyl)imidazole and 1-N-(ferrocenylmethyl)-1,2,4-triazole with long chain alkyl bromides. The synthesized ILs were screened for their anticancer activity against human breast cancer cell line MCF-7. ILs 2a–d and 4b displayed significant anticanc...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
In this study, whole genome comparative genomic hybridization array (array CGH) based genomic analysis was performed on twelve Saudi Lynch syndrome patients. A total of 124 chromosomal alterations (structural loss) were identified at mean log2 ratio cut off value of ±0.25. We also found structural loss in 2p21-p16.3, 3p23-p14.2, 7p22.1 and 1p34.1-p33 regions. These findings were subsequently validated by real time quantitative PCR showing downregulation of MSH2, MSH6, EPCAM, MLH1, PMS2 and MUTYH genes. These findings shall help in establishing database for alterations in mismatch repair genes underlying Lynch syndro...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Publication date: 1 October 2019Source: Sensors and Actuators B: Chemical, Volume 296Author(s): Chammari Pothipor, Natta Wiriyakun, Thitirat Putnin, Aroonsri Ngamaroonchote, Jaroon Jakmunee, Kontad Ounnunkad, Rawiwan Laocharoensuk, Noppadol AroonyadetAbstractRecent studies show that electrochemical biosensors offer simple, robust and low-cost solution for point-of-care applications. To meet rigorous requirements of early disease diagnosis and other medical applications, nanomaterials have been investigated to increase sensitivity and selectivity of electrochemical sensors. Herein, we successfully developed graphene-poly(3-...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Abstract The underlying molecular basis for neurodevelopmental or neuropsychiatric disorders is not known. In contrast, mechanistic understanding of other brain disorders including neurodegeneration has advanced considerably. Yet, these do not approach the knowledge accrued for many cancers with precision therapeutics acting on well-characterized targets. Although the identification of genes responsible for neurodevelopmental and neuropsychiatric disorders remains a major obstacle, the few causally associated genes are ripe for discovery by focusing efforts to dissect their mechanisms. Here, we make a case for del...
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Tags: CNS Neurosci Ther Source Type: research
Authors: Albisinni S, Pretot D, Al Hajj Obeid W, Aoun F, Quackels T, Peltier A, Roumeguère T Abstract INTRODUCTION: The neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) are established markers of systemic inflammation. Moreover, anemia is a known adverse prognostic factor and reduced haemoglobin to platelet ratio (HPR) seems associate to poor outcomes in urothelial cancer. Aim of the current study was to explore the prognostic value of NLR, HPR and PLR in patients harboring localized RCC. Materials and Methods 184 patients undergoing partial and radical nephrectomy for renal ma...
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
Publication date: Available online 15 June 2019Source: Molecular Genetics and MetabolismAuthor(s): Yoshiyuki Okano, Toshihiro Ohura, Osamu Sakamoto, Ayano InuiAbstractIdentification of the genes responsible for adult-onset type II citrullinemia (CTLN2) and citrin protein function have enhanced our understanding of citrin deficiency. Citrin deficiency is characterized by 1) neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD); 2) adaptation/compensation stage with unique food preference from childhood to adulthood; and 3) CTLN2. The treatment of NICCD aims to prevent the progression of cholestasis, and it i...
Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research
Contributors : Shaoqing Ju ; Xianjuan ShenSeries Type : OtherOrganism : Homo sapiensPurpose: With the advent of human genome sequencing project, circRNAs attracted widespread attention in cancer research due to its stable ring structure. Our aim was to identify differentially expressed circRNAs in GC and explore their potential roles in GC diagnosis and treatment.Methods: Total RNA from tissues was isolated by Hipure Total RNA Mini Kit (Magen, Germany). Qubit 3.0 Fluorometer (Invitrogen, Carlsbad, California) was used for RNA concentration measurement while Agilent 2100 Bioanalyzer (Applied Biosystems, Carlsbad, CA) for RN...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Publication date: Available online 15 June 2019Source: European UrologyAuthor(s): Noel Clarke, Heather Payne, Jan van der Meulen
Source: European Urology - Category: Urology & Nephrology Source Type: research
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