Better gene knockout in aneuploid cell lines

(Mary Ann Liebert, Inc./Genetic Engineering News) CRISPR/Cas9 technology enables convenient and effective genome editing in diploid cell lines based on the isolation and expansion of edited single-cell clones. However, this approach is ineffective for aneuploid cell lines, and a group has now reported an improved method for genome editing based on multiple rounds of modification.

Source: EurekAlert! - Biology - May 23, 2019 Category: Biology Source Type: news