Scientists spy on superbugs to see how they outsmart our antibiotics

Scientists have discovered yet another way that single-celled organisms have outsmarted us.The tiny bacteria that live inside our guts have an ingenious way of withstanding the onslaught of antibiotics we throw at them, according to a report published Thursday in the journalScience. The two-part...
Source: Los Angeles Times - Science - Category: Science Authors: Source Type: news

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Publication date: Available online 15 October 2019Source: Journal of Molecular Graphics and ModellingAuthor(s): Rida Sajjad, Sajjad Ahmad, Syed Sikander AzamAbstractGlobally, antibiotic-resistant and tolerated bacterial isolates of Acinetobacter species are imposing high financial cost on health care systems and as such, molecular targets with promising immune protection could provide substantive benefits to human healthcare. Here, we performed an in silico based proteome-wide screening for antigenic B-cell derived T-cell epitopes and their following use to design a multi-epitope peptide vaccine that can effectively engage...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
Authors: Bader MS, Loeb M, Leto D, Brooks AA Abstract Urinary tract infections (UTIs) caused by antibiotic- resistant Gram-negative bacteria are a growing concern due to limited treatment options. Knowledge of the common uropathogens in addition to local susceptibility patterns is essential in determining appropriate empiric antibiotic therapy of UTIs. The recommended first-line empiric antibiotic therapy for acute uncomplicated bacterial cystitis in otherwise healthy adult nonpregnant females is a 5-day course of nitrofurantion, a 3-g single dose of fosfomycin tromethamine, or a 5-day course of pevmecillinam. High...
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
In conclusion, to best of our knowledge these findings are the first report of isolation of 4-bromophenol and Bis (2-ethylhexyl) phthalate from genus Nocardiopsis, thus suggesting that rare actinomycetes are promising source of therapeutically important bioactive metabolites.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Electron microscopy revealed a world that exists at scales smaller than the wavelength of light. Advancements in this field have allowed scientists to visualize ever more objects and processes, but actually seeing living cells in 3D and within a liqu...
Source: Medgadget - Category: Medical Devices Authors: Tags: Diagnostics Materials Nanomedicine News Oncology Pathology Radiology microscopy Source Type: blogs
New options are urgently needed for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. Balsacone C is a new dihydrochalcone extracted from Populus balsamifera that has been reported previously as being active against Staphylococcus aureus. Here, we evaluate the antibacterial activity of balsacone C against MRSA. Thirty-four (34) MRSA isolates were obtained from hospitalized patients; these isolates were then characterized for their resistance. Most of these MRSA (>85%) were resistant to penicillin, amoxicillin/clavulanic acid, ciprofloxacin, moxifloxacin, levofloxacin, clindamycin, erythromy...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In this study we demonstrate that the supernatant from novel environmental isolates of Delftia spp. have antimicrobial activity. We characterized the active fraction and identified delftibactin A as a compound with antimicrobial activity. Delftibactin A exhibits potent antimicrobial activity against Gram positive multi drug resistant (MDR) bacteria like Methicillin-resistant Staphylococcus aureus (MRSA), and Vancomycin resistant Enterococcus (VRE), and also against the Gram negative pathogens Acinetobacter baumannii and Klebsiella pneumoniae. We discovered that the production of delftibactin A is greatly influenced by temp...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
There is a global crisis of antibiotic resistance, and urinary tract infections (UTIs) may be the canary in the coal mine. UTIs are one of the most common types of infections; at least one in two women and one in 10 men will experience a UTI in their lifetime. Like many human infections, UTIs are usually caused by bacteria living on or in our bodies, and require treatment with antibiotics. What’s alarming the medical community now is that UTIs are becoming ever harder to treat with common antibiotics. Antibiotic overuse leads to antibiotic resistance At some point, most people have taken a course of trimethoprim/sulf...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Drugs and Supplements Health Infectious diseases Kidney and urinary tract Women's Health Source Type: blogs
AbstractVarious transient metal and metal oxide nanoparticles (NPs) have shown pronounced biological activity, including antibacterial action against different Gram-negative and Gram-positive bacteria including pathogens and drug-resistant ones. Thus, NPs can be applied in nanotechnology for controlling bacterial growth as well as in biomedicine for the treatment of various diseases. However, the mechanisms of these effects are not clear yet. This review is focused on the antibacterial effects of transient metal NPs, especially iron oxide (Fe3O4) and Ag NPs onEscherichia coli wild type and antibiotic-resistant strains. Ag ...
Source: World Journal of Microbiology and Biotechnology - Category: Microbiology Source Type: research
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Source: Hospital Practice - Category: Hospital Management Authors: Source Type: research
In this study, thermal activation was opted for the modification of natural bentonite clay (BC) and utilized to investigate the adsorptive removal of tetracycline (TC) from aqueous solution. The physicochemical surface properties of the raw and modified bentonite samples were also investigated. The BET analysis revealed that the thermally activated bentonite (TB) has better properties than BC. The surface area of TB was found to be more than two-fold higher compared to that of BC. The FTIR spectra exhibited the existence of AlOH, SiO and SiOSi functional groups in the samples, confirming the presence of hydrated aluminosil...
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
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