Brain metastasis in epithelial ovarian cancer by BRCA1/2 mutation status.

CONCLUSION: This is the largest study to date comparing outcomes in patients with EOC and BM by mutation status. mBRCA patients were more likely to have isolated BM, which may be a factor in their long survival. This supports the pursuit of aggressive treatment for mBRCA EOC patients with BM. Additional studies examining the correlation of BRCA mutational status with BM are warranted.
PMID: 31113680 [PubMed - as supplied by publisher]

Source: Gynecologic Oncology - May 17, 2019 Category: Cancer & Oncology Authors: Stasenko M, Cybulska P, Feit N, Makker V, Konner J, O'Cearbhaill RE, Alektiar KM, Beal K, Gardner GJ, Long Roche KC, Sonoda Y, Chi DS, Zivanovic O, Leitao MM, Cadoo KA, Tew WP Tags: Gynecol Oncol Source Type: research